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Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 205 ()

This study aimed to investigate the protective effect of melatonin on the corneal epithelium in dry eye disease (DED) and explore its underlying mecha......

Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 206 ()

Many long non-coding RNAs (lncRNAs) can exert crucial roles in the pathogenesis of cataract, including lncRNA KCNQ1 opposite strand/antisense transcri......

Comparison of A-Scan ultrasonography and the Lenstar optical biometer in Guinea pig eyes

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 207 ()

Objective: To compare the biometric parameters provided by A-scan ultrasonography and the Lenstar optical biometer in guinea pig eyes, including anter......

Novel variants in GUCY2D causing retinopathy and the genotype-phenotype correlation

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 208 ()

Leber congenital amaurosis (LCA) is the most severe form of retinopathy and cone/cone-rod dystrophy (CORD) is a common form of inherited retinopathy. ......

Contribution of M-opsin-based color vision to refractive development in mice

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 209 ()

M-opsin, encoded by opn1mw gene, is involved in green-light perception of mice. The role of M-opsin in emmetropization of mice remains uncertain. To a......

Exosome-transmitted circ-CARD6 facilitates posterior capsule opacification development by miR-31/FGF7 axis

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 207 ()

Background: Posterior capsular opacification (PCO) is the major vision-disrupting complication arising after cataract surgery. Circular RNAs (circRNAs......

N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1 beta signaling pathway

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 209 ()

Diabetes mellitus (DM) induces damage to the ocular surface, which leads to vision decline. In the current study, we investigated whether N-acetylcyst......

Forkhead domain inhibitory-6 attenuates subconjunctival fibrosis in rabbit model with trabeculectomy

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 210 ()

Antiproliferative therapies are crucially important for improving the success rate of the glaucoma filtration surgeries. In this study, we investigate......

Geniposide alleviates choroidal neovascularization by downregulating HB-EGF release from RPE cells by downregulating the miR-145-5p/ NF-KB axis

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 208 ()

Age-related macular degeneration (AMD), mainly wet AMD, is the major reason for nonreversible vision loss worldwide. Choroidal neovascularization (CNV......

Kruppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 207 ()

Objective: The purpose of this study is to investigate the effects of Kruppel-like factor 7 (KLF7) on retinal ganglion cells (RGCs) and retinal functi......

VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 209 ()

Diabetic retinopathy (DR) has been considered to involve mitochondrial alterations and be related to the nucleotide-binding oligomerization domain-lik......

The association between circulating neutrophil extracellular trap related biomarkers and retinal vein occlusion incidence: A case-control pilot study

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 210 ()

Retinal vein occlusion (RVO) is the second most common retinal vascular disorders and causes visual damage in a large population. Neutrophil extracell......

Meibum lipid composition in type 2 diabetics with dry eye

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 206 ()

Purpose: The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) an......

Long-term multimodal imaging characterization of persistent retinal neovascularization using DL-alpha-aminoadipic acid in pigmented and white rabbits

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 207 ()

Purpose: Intravitreal (IVT) injection of DL-alpha-aminoadipic acid (AAA) is a new animal model for retinal neovascularization (RNV) reported in rabbit......

Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model

期刊: EXPERIMENTAL EYE RESEARCH, 2021; 209 ()

In this study, a macro-indentation test on the submillimeter scale was performed to analyze the indentation behavior of an intact cornea under physiol......

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