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Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-beta 1 in renal fibrosis

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (4)

We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF). We firstly modeled adriamycin-induced rat RF with unilateral nephre......

Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (1)

Schizophrenia is one of the foremost psychological illness around the world, and recent evidence shows that inflammation and oxidative stress may play......

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (1)

This study aimed to investigate the therapeutic potential of human umbilical cord mesenchymal stem cells derived exosomes (hUCMSC-Exo) in acute liver ......

Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (1)

Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current......

Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (1)

High-mobility group box 1 (HMGB1), a highly conserved chromosome protein, is considered as a potential therapeutic target and novel biomarker because ......

Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-kappa B and MAPK signaling pathways

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (4)

Aims: To investigate the effect of dencichine on osteoclastogenesis in vivo and in vitro. Methods: RANKL-induced osteoclastogenesis were treated with ......

CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (1)

Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced n......

Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (2)

Polygala japonica Houtt. (PJ), a member of the Polygala L. family that is suggested to exhibit detoxification properties in traditional Chinese medici......

Liraglutide ameliorates diabetes-associated cognitive dysfunction via rescuing autophagic flux

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (3)

The incidence of diabetes-associated cognitive dysfunction is increasing. However, few clinical interventions are available to prevent the disorder. S......

Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (4)

Momordin Ic (MI) is a natural pentacyclic triterpenoid enriched in various Chinese natural medicines such as the fruit of Kochia scoparia (L.) Schrad.......

circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (1)

Circular RNAs (circRNAs) have been shown to be involved in the progression of many diseases, including cancer. However, the role of circ_0101802 in th......

LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (3)

The incidence rate of nasopharyngeal carcinoma (NPC) is the highest among the malignant tumors of otorhinolaryngology, posing a huge burden to public ......

Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 147 (3)

Sesamin is a lignan compound in plants that has various pharmacological effects, including reducing diabetes-associated injuries, regulating fatty aci......

Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/beta-Catenin/CaMKIV pathway

期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021; 146 (2)

Objective: To investigate the effect of sevoflurane on inflammation of microglia in hippocampus of neonatal rats, and to investigate whether the relat......

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