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Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment

期刊: GEROSCIENCE, 2022; 44 (4)

Exploring individual hallmarks of brain ageing is important. Here, we propose the age-related glucose metabolism pattern (ARGMP) as a potential index ......

Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow

期刊: GEROSCIENCE, 2022; 44 (4)

Aging is a progressive loss of physiological function and increased susceptibility to major pathologies. Degenerative diseases in both brain and bone ......

Untapped research opportunities in China: promising future avenues and potential concerns for aging companion animals

期刊: GEROSCIENCE, 2022; 44 (3)

Companion animals have recently been proposed as ideal translational models of human aging due to their shared susceptibility for certain diseases, si......

Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence

期刊: GEROSCIENCE, ; ()

Our previous studies found that deletion of nuclear receptor interacting protein 1 (Nrip1) extended longevity in female mice and delayed cell senescen......

Implication of post-translationally modified SOD1 in pathological aging

期刊: GEROSCIENCE, ; ()

Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of ......

Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration

期刊: GEROSCIENCE, ; ()

The prevalence of rheumatic and musculoskeletal diseases (RMDs) including osteoarthritis (OA) and low back pain (LBP) in aging societies present signi......

Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study

期刊: GEROSCIENCE, ; ()

It is well established from previous cross-sectional studies that telomeres shorten with age. However, due to a considerable inter-individual variatio......

n-3 polyunsaturated fatty acids as modulators of thermogenesis in Ames dwarf mice

期刊: GEROSCIENCE, 2020; 42 (3)

Lipids, commonly split into saturated and mono- and polyunsaturated fatty acids, are key constituents of all biological membranes, and their exact pro......

CD82-TRPM7-Numb signaling mediates age-related cognitive impairment

期刊: GEROSCIENCE, 2020; 42 (2)

Aging is a crucial cause of cognitive decline and a major risk factor for Alzheimer's disease (AD); however, AD's underlying molecular mechanisms rema......

Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction

期刊: GEROSCIENCE, 2020; 42 (2)

Individuals with diabetes are more susceptible to cerebral vascular aging. However, the underlying mechanisms are not well elucidated. The present stu......

A short life on the farm: aging and longevity in agricultural, large-bodied mammals

期刊: GEROSCIENCE, 2020; 42 (3)

As average human lifespans increase across the globe, companion animals, specifically dogs and cats, are also living longer with more age-related morb......

Inducible aging inHydra oligactisimplicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways

期刊: GEROSCIENCE, 2020; 42 (4)

Freshwater polyps of the genusHydrado not age. However, temperature stress induces aging and a shift from reproduction by asexual budding to sexual ga......

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

期刊: GEROSCIENCE, 2020; 42 (5)

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present st......

Companion animals likely do not spread COVID-19 but may get infected themselves

期刊: GEROSCIENCE, 2020; 42 (5)

Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SAR......

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