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Comprehensive evaluation of protein-coding sORFs prediction based on a random sequence strategy

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (8)

Background: Small open reading frames (sORFs) with protein-coding ability present unprecedented challenge for genome annotation because of their short......

UPF1: a potential biomarker in human cancers

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (5)

Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor pro......

PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (8)

Background: Evidences has showed that procollagen-lysine 2-oxoglutarate 5-dioxygenase 1 (PLOD1) participated in the many cancers' progression, such as......

Prediction of diabetic protein markers based on an ensemble method

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (7)

Introduction: A diabetic protein marker is a type of protein that is closely related to diabetes. This kind of protein plays an important role in the ......

Improved prediction of drug-target interactions based on ensemble learning with fuzzy local ternary pattern

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (7)

Introduction: The prediction of interacting drug-target pairs plays an essential role in the field of drug repurposing, and drug discovery. Although b......

Nanog promotes stem-like traits of glioblastoma cells

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (3)

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examin......

AGEs promote calcification of HASMCs by mediating Pi3k/AKT-GSK3 beta signaling

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (6)

This study aimed to investigate the effects of advanced glycation end products (AGEs) on the calcification of human arterial smooth muscle cells (HASM......

ITGBL1 promotes gastric cancer cell proliferation and invasion via Akt signal pathway

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (4)

Integrin beta- like 1 (ITGBL1), an extracellular matrix protein, plays an oncogenic role in diverse forms of cancers. To this end, we examined the imp......

Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (4)

Ovarian serous adenocarcinoma is one of the most common and fatal malignancies among women worldwide. The tumor microenvironment plays a critical role......

Kinesin superfamily proteins: roles in osteosarcoma

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (8)

Background: Osteosarcoma is a common bone tumor with extremely high malignancy, occurring mostly in children and adolescents. At present, the survival......

Evaluation of the efficiency of the imperative ecological remediation regarding tree growth, root development, and edaphic properties after Typhoon Hato (2017) in Zhuhai, China

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (8)

Background: urban forest in coastal cities encounters multiple disturbances of frequent typhoon events caused by global change, under which ecological......

Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (8)

Background: The CTNND2 gene which encodes a delta-catenin protein (CTNND2) is associated with multi-ple severe neurological disorders. However, the sp......

The role of circular RNAs in brain and stroke

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (5)

Circular RNAs are single-stranded RNAs which are closed by covalent bonds during splicing. Different from other RNAs, circular RNAs are well known due......

Analgesic effect of dl-THP on inflammatory pain mediated by suppressing spinal TRPV1 and P2X3 receptors in rats

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (5)

Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanism......

HSC70-JNK-BAG3 complex is critical for cardiomyocyte protection of BAG3 through its PXXP and BAG structural domains

期刊: FRONTIERS IN BIOSCIENCE-LANDMARK, 2021; 26 (6)

Notwithstanding previous studies have proved the anti-apoptotic effect of Bcl-2 associated athanogene3 (BAG3) in myocardium, the structural domains PX......

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