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Proharziane and Harziane Derivatives from the Marine Algicolous Fungus Trichoderma asperelloides RR-dl-6-11

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (4)

One new proharziane and three new harziane derivatives (1-4) together with six known ones (5-10) were isolated from the marine-alga-derived ascomycete......

Cryptoyunnanones A-H, Complex Flavanones from Cryptocarya yunnanensis

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (1-8), together with four known alpha-pyrones, were isolated from the leaves a......

Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

A bioactivity-guided study on the leaves of Picrasma javanica led to the isolation of 19 quassinoids, including 13 new compounds. The structures of th......

New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (4)

Three new tyramine-type alkamides (1-3), three new natural products (4-6), five new N-acylated/formylated aporphine alkamides with different ratios of......

Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (5)

Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple technique......

Targeted Discovery of the Polyene Macrolide Hexacosalactone A from Streptomyces by Reporter-Guided Selection of Fermentation Media

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (7)

New approaches are still needed to fully explore the biosynthetic potential of microbes. We recently devised a melC reporter-guided fermentation media......

Epigenetic Manipulation to Trigger Production of Guaiane-Type Sesquiterpenes from a Marine-Derived Spiromastix sp. Fungus with Antineuroinflammatory Effects

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (7)

Epigenetic manipulation of a deep-sea sediment-derived Spiromastix sp. fungus using suberoylanilide hydroxamic acid (SAHA) induction resulted in the a......

Visible-Light-Promoted Biomimetic Reductive Functionalization of Quaternary Benzophenanthridine Alkaloids

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

Reduction of an iminium C = N double bond is the most important phase I metabolism process associated with the cytotoxic property of quaternary benzop......

Structural Revision of Guttiferone F and 30-epi-Cambogin

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (4)

Guttiferone F, a natural polyprenylated polycyclic acylphloroglucinol, was originally assigned as the 30-epimer of garcinol by NMR data analyses. Conv......

Taccachatrones A-G, Highly Oxidized Steroids from the Rhizomes of Tacca chantrierii and Their Cytotoxicity Assessment

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

Seven highly oxidized steroids, taccachatrones A-G (1-7), together with four known taccalonolides (8-11), were characterized from the rhizomes of Tacc......

Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (4)

Porcine epidemic diarrhea virus (PEDV) has become increasingly problematic around the world, not only for its hazards to livestock but also due to the......

Heterologous Biosynthesis of Tetrahydroxanthone Dimers: Determination of Key Factors for Selective or Divergent Synthesis

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (5)

Tetrahydroxanthone dimers are fungal products, among which secalonic acid D (1) is one of the most studied compounds because of its potent biological ......

Iridoid Constituents of Viburnum brachybotryum

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (7)

Eleven new iridoids, brachybones A-K (1-11), were isolated from the twigs of Viburnum brachybotryum. Their structures including absolute configuration......

Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

Two novel rearranged Diels-Alder adducts, morunigrines A (1) and B (2), and four new prenylated flavonoids, morunigrols A-D (3-6), were isolated from ......

Fusaricide is a Novel Iron Chelator that Induces Apoptosis through Activating Caspase-3

期刊: JOURNAL OF NATURAL PRODUCTS, 2021; 84 (8)

Nonsmall cell lung cancer (NSCLC) has been a fatal and refractory disease worldwide. Novel therapeutic developments based on fundamental investigation......

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