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Antidepressant-like effect and phytochemical profile of supercritical CO2 extract from Citri reticulatae pericarpium

期刊: PHARMAZIE, 2021; 76 (6)

Citri reticulatae pericarpium is a condiment, adding much flavor in Chinese food. Also it can be used to treat depression as a Traditional Chinese Med......

A novel fixed-dose combination treatment for chronic hepatitis C, based on NS5A inhibitor fopitasvir and NS5B inhibitor sofosbuvir

期刊: PHARMAZIE, 2021; 76 (8)

Drug resistance caused by the extreme genetic variability of zhe hepatitis C virus has rendered effective combinations of drugs indispensable in the t......

Efficacy of atezolizumab to treat non-small-cell lung cancer: a meta-analysis based on randomized clinical trials

期刊: PHARMAZIE, 2021; 76 (5)

Purpose: Atezolizumab, an immunoglobulin G1 monoclonal antibody against PD-L1, is accepted to treat advanced non-small-cell lung cancer (NSCLC). Our s......

Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora

期刊: PHARMAZIE, 2021; 76 (5)

The effects of eight oral anti-coronavirus drugs (lopinavir, ritonavir, chloroquine, darunavir, ribavirin, arbidol, favipiravir, oseltamivir) on the m......

Effects of different concentrations of metformin on osteoclast differentiation and apoptosis and its mechanism

期刊: PHARMAZIE, 2021; 76 (6)

This study aimed to investigate the effect of metformin on osteoclast differentiation and apoptosis. Low concentration of metformin inhibited osteocla......

Pharmacokinetics of abiraterone acetate released from a tablet based on lipid matrix in beagle dogs

期刊: PHARMAZIE, 2021; 76 (7)

Objective: To compare the pharmacokinetic behavior of abiraterone acetate after oral administration of a lipid-based formulation tablet and a referenc......

The decrease of T3 / T4 is not hypothyroidism - a new mutation of Serpina7 gene results in partial thyroglobulin deficiency

期刊: PHARMAZIE, 2021; 76 (9)

To explore an unusual cause of the decrease of T3/T4 through a new mutation of TBG gene in a family, so as to avoid habitual thinking and reduce subse......

20(S)-Ginsenoside Rg3 regulates the Hedgehog signaling pathway to inhibit proliferation and epithelial-mesenchymal transition of lung cancer cells

期刊: PHARMAZIE, 2021; 76 (9)

20(S)-Ginsenoside Rg3 (S-Rg3) has good antitumor activity and has been used in clinical oral antitumor therapy. However, the effect of S-Rg3 on the He......

Coptisine induces G2/M arrest in esophageal cancer cell via the inhibition of p38/ERK1/2/claudin-2 signaling pathway

期刊: PHARMAZIE, 2021; 76 (5)

In this study, we treated esophageal cancer (EC) cell lines, TE1 and KYSE450 with coptisine (COP) and investigated the biological effects of COP in EC......

Status of hypoxia-inducible factor-1 alpha expression in non-small cell lung cancer

期刊: PHARMAZIE, 2021; 76 (9)

According to the latest statistics from WHO for all cancers, lung cancer tops the list with a 14.5% prevalence and a 22% death rate in men, similar to......

The role of vascular endothelial growth factor in ischemic stroke

期刊: PHARMAZIE, 2021; 76 (4)

Ischemic stroke is an injury caused by temporary or permanent cerebral vascular occlusion. It has a high incidence, mortality, and disability rate in ......

Berberine prevents diabetic retinopathy through inhibiting HIF-1 alpha/VEGF/NF-kappa B pathway in db/db mice

期刊: PHARMAZIE, 2021; 76 (4)

Our paper investigated the effect of berberine on the diabetic retinopathy (DR) in db/db transgenic mice and explored its possible mechanisms. During ......

MiR-877-5p targets PDK-1 to promote aspirin-induced apoptosis in gastric mucosal cells

期刊: PHARMAZIE, 2021; 76 (6)

This study aimed to investigate the role of miR-877-5p in aspirin-induced gastric mucosal injury. MiRNA microarray analysis was performed using paired......

Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression

期刊: PHARMAZIE, 2021; 76 (9)

MicroRNAs are emerging as important endogenous regulators of gene function and they are playing an important role in the occurrence and development of......

Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect

期刊: PHARMAZIE, 2021; 76 (5)

Anisodamine exerts significant protective effect on ischemia/reperfusion (I/R) injury in various organs. However, little is known about the mechanisms......

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