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Contribution of sample processing to gut microbiome analysis in the model Lepidoptera, silkworm Bombyx mori

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Microbes that live inside insects play various roles in host biology, ranging from nutrient supplementation to host defense. Although Lepidoptera (but......

Employing hypoxia characterization to predict tumour immune microenvironment, treatment sensitivity and prognosis in hepatocellular carcinoma

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

The hypoxic microenvironment was recognized as a major driving force of the malignant phenotype in hepatocellular carcinoma (HCC), which contributes t......

Beyond samples: A metric revealing more connections of gut microbiota between individuals

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Studies of gut microbiota explore their complicated connections between individuals of different characteristics by applying different metrics to abun......

Review on circular RNAs and new insights into their roles in cancer

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precurso......

Meta-analysis of transcriptome datasets: An alternative method to study IL-6 regulation in coronavirus disease 2019

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

In coronavirus disease 2019 (COVID-19) patients, interleukin (IL)-6 is one of the leading factors causing death through cytokine release syndrome. Hen......

Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

The outer membrane (OM) of Gram-negative bacteria is a formidable barrier against antibiotics. Understanding the structure and function of the OM is e......

Deep learning for COVID-19 chest CT (computed tomography) image analysis: A lesson from lung cancer

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

As a recent global health emergency, the quick and reliable diagnosis of COVID-19 is urgently needed. Thus, many artificial intelligence (AI)-base met......

Interpopulation differences of retroduplication variations (RDVs) in rice retrogenes and their phenotypic correlations

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Retroduplication variation (RDV), a type of retrocopy polymorphism, is considered to have essential biological significance, but its effect on gene fu......

De novo mutations in folate-related genes associated with common disorders

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Folate deficiency is an environmental risk factor for several developmental disorders. De novo mutations (DNMs) also play important etiological roles ......

Clp is a "busy" transcription factor in the bacterial warrior, Lysobacter enzymogenes

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Cyclic AMP receptor protein (CRP) is a well-characterized group of global transcription factors in bacteria. They are known to regulate numerous cellu......

Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Safer and more-effective drugs are urgently needed to counter infections with the highly pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identi......

Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Colorectal cancer (CRC) results from the uncontrolled growth of cells in the colon, rectum, or appendix. The 5-year relative survival rate for patient......

FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

The use of herbs to treat various human diseases has been recorded for thousands of years. In Asia's current medical system, numerous herbal formulas ......

Comparisons of the immunological landscape between COVID-19, influenza, and respiratory syncytial virus patients by clustering analysis

期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 ()

Background: COVID-19 has stronger infectivity and a higher risk for severity than most other contagious respiratory illnesses. The mechanisms underlyi......

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