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Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 339 ()

Salidroside has been identified as one of the most potent compounds isolated from various Rhodiola plants, which have been used for a long time as ada......

Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 340 ()

Background: Breast cancer is a complex disease. Recent research has examined the anticancer effects of dihydroartemisinin (DHA) on breast cancer. Howe......

Amentoflavone from Selaginella tamariscina as a potent inhibitor of gut bacterial beta-glucuronidase: Inhibition kinetics and molecular dynamics stimulation

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 340 ()

Gut bacterial beta-glucuronidase (GUS) plays a pivotal role in the metabolism and reactivation of a vast of glucuronide conjugates of both endogenous ......

Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 344 ()

As the sixth most prevalent cancer, liver cancer has been reported as the second cause of cancer-induced deaths globally. Lysionotin, a flavonoid comp......

Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 345 ()

Pyroptosis plays an important role in the pathogenesis of numerous infectious, autoimmune, and inflammatory diseases, which makes it a promising targe......

Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 347 ()

It has been reported that Dendrobium officinale polysaccharides (DOPS) could alleviate colitis in animal model and suppress the activation of NLRP3 in......

Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 345 ()

Soluble epoxide hydrolase (sEH) is a potential drug target to treat inflammation and neurodegenerative diseases. In this study, we found that the extr......

JNK-mediated blockage of autophagic flux exacerbates the triethylene glycol dimethacrylate-induced mitochondrial oxidative damage and apoptosis in preodontoblast

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 339 ()

Mitochondrial dependent oxidative stress (OS) and subsequent cell death are considered as the major cytotoxicity caused by Triethylene glycol dimethac......

Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 345 ()

Sepsis triggers liver dysfunction with high morbidity and mortality. Here, we elucidated the effect of anemoside B4 on sepsis in cecal ligation and pu......

Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 345 ()

Advanced glycation end products (AGEs) are associated with the pathogenesis of diabetic vascular complications. Induction of the endothelial-to-mesenc......

iTRAQ-based quantitative proteomics and network pharmacology revealing hemostatic mechanism mediated by Zingiberis Rhizome Carbonisata in deficiency-cold and Hemorrhagic Syndrome rat models

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 343 ()

Zingiberis Rhizome Carbonisata (ZRC) has been used as a hemostatic agent in traditional Chinese medicine (TCM). However, the underlying molecular mech......

Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 347 ()

Cell injury is a necessary and critical event during CaOx kidney stone formation. Sirt1 exerts a number of pleiotropic effects, protecting against ren......

Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 342 ()

The development of multi-target-directed ligands (MTDLs) may improve complex central nervous system diseases such as Alzheimer's disease (AD). Here, a......

Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 343 ()

The drug-drug interaction (DDI) risk of phenytoin with several topical formulations of miconazole is still unclear. The present investigation conducte......

Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway

期刊: CHEMICO-BIOLOGICAL INTERACTIONS, 2021; 341 ()

The pathogenesis of rheumatoid arthritis (RA) is characterized by synoviocyte hyperplasia and proinflammatory cytokine secretion, as well as the destr......

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