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The Impact of Air Pollution on Neurodegenerative Diseases

期刊: THERAPEUTIC DRUG MONITORING, 2021; 43 (1)

Background: With the development of industrialization in human society, ambient pollutants are becoming more harmful to human health. Epidemiological ......

A Direct Injection Technique to Improve Biosafety to Analyze Levetiracetam Concentrations in Human Serum and Its Application in Therapeutic Drug Monitoring

期刊: THERAPEUTIC DRUG MONITORING, 2021; 43 (2)

Background: With the outbreak of COVID-19, it has become very important to improve biosafety measures taken by medical staff. Fewer pretreatment steps......

Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (2)

Background: In the United States, drug addiction has become a nationwide health crisis. Recently, buprenorphine (BUP), a maintenance therapy approved ......

Excretion of Antipsychotics Into the Amniotic Fluid, Umbilical Cord Blood, and Breast Milk: A Systematic Critical Review and Combined Analysis

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (2)

Background: Antipsychotics are being increasingly prescribed during pregnancy and in the postpartum period. However, knowledge regarding the ability o......

Evaluation of Concentration Errors and Inappropriate Dose Tailoring of Tacrolimus Caused by Sampling-Time Deviations in Pediatric Patients With Primary Nephrotic Syndrome

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (3)

Background: Tacrolimus dosing is routinely tailored based on its trough level (C-0) drawn by therapeutic drug monitoring in pediatric patients with pr......

A Retrospective Analysis of Steady-State Olanzapine Concentrations in Chinese Patients Using Therapeutic Drug Monitoring: Effects of Valproate and Other Factors

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (4)

Background: The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chines......

Prediction of Serum-Free and Cerebrospinal Fluid Valproic Acid Levels in Patients With Hypoalbuminemia After Craniotomy

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (4)

Background: In patients with hypoalbuminemia after craniotomy, total serum concentrations of valproic acid (VPA) may provide poor clinical insights, o......

Therapeutic Drug Monitoring Coupled With Bayesian Forecasting Could Prevent Vancomycin-Associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (4)

Background: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring (TDM) is recommended. Bayesian forecasti......

Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (4)

Background: Critically ill patients show several pathophysiological alterations that can complicate antibiotic dosing. Hence, there is a strong ration......

Subtherapeutic Linezolid Concentration in a Patient With Bullous Pemphigoid Complicated by Methicillin-ResistantStaphylococcus aureusInfection: A Case Study

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (4)

We presented a case of subtherapeutic linezolid concentration in a patient with bullous pemphigoid characterized by large area skin anabrosis complica......

Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (6)

Background: Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors ......

Safety and Efficacy of Tigecycline in Intensive Care Unit Patients Based on Therapeutic Drug Monitoring

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (6)

Objective: Tigecycline exerts significant beneficial effects against drug-resistant bacterial infections. The largely empirical medications used in cl......

Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (5)

Background: The aim of the study was to investigate how age and genetic polymorphisms ofUGT1A6andUGT2B7contribute to the concentrations of valproic ac......

Cefotiam Treatment in Children: Evidence of Subtherapeutic Levels

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (5)

Background: Cefotiam, a second-generation cephalosporin, is a broad-spectrum antibiotic with good antibacterial action against both gram-negative and ......

A Simple and Robust Liquid Chromatography With Tandem Mass Spectrometry Analytical Method for Therapeutic Drug Monitoring of Plasma and Cerebrospinal Fluid Polymyxin B1 and B2

期刊: THERAPEUTIC DRUG MONITORING, 2020; 42 (5)

Background: Polymyxin B is used as the last treatment resort for multidrug-resistant gram-negative bacterial infections. This study aimed to develop a......

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