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MiR-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via PTEN downregulation-mediated activation of AKT/mTOR pathway

期刊: BRAIN RESEARCH, 2021; 1768 ()

Background: Multiple cellular and molecular changes are involved in the etiology of spinal cord injury (SCI) and the recovery from SCI. Accumulating s......

CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid beta-induced neuronal injury in Alzheimer's Disease

期刊: BRAIN RESEARCH, 2021; 1770 ()

Background: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognition and language impairment. C......

Neural mechanism for dynamic distractor processing during video target detection: Insights from time-varying networks in the cerebral cortex

期刊: BRAIN RESEARCH, 2021; 1765 ()

In dynamic video target detection tasks, distractors may suddenly appear due to the dynamicity of the visual scene and the uncertainty of the visual i......

SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/beta-catenin signaling via modulation of the Akt/GSK-3 beta axis

期刊: BRAIN RESEARCH, 2021; 1765 ()

Spindle and kinetochore-related complex subunit 3 (SKA3) is a key modulator of the progression of multiple tumor types. However, the involvement of SK......

Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/ miR-633/ROCK1 axis

期刊: BRAIN RESEARCH, 2021; 1767 ()

Background: Sevoflurane is a common inhalational anesthetic, which has been revealed to have anticancer effect in glioma. However, the mechanisms of s......

CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway

期刊: BRAIN RESEARCH, 2021; 1764 ()

Background: Circular RNAs (circRNAs) are found to regulate glioblastoma evolution. However, the role of circATP binding cassette subfamily C member 3 ......

GSK-3 beta inhibitor TWS119 alleviates hypoxic-ischemic brain damage via a crosstalk with Wnt and Notch signaling pathways in neonatal rats

期刊: BRAIN RESEARCH, 2021; 1768 ()

Preterm infant brain injury is a leading cause of morbidity and disability in survivors of preterm infants. Unfortunately, the effective treatment rem......

Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-cB and STAT1 pathway

期刊: BRAIN RESEARCH, 2021; 1770 ()

Microglial polarization mediated neuroinflammation plays an important role in the pathological process of stroke. The aim of this study is to determin......

Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice

期刊: BRAIN RESEARCH, 2021; 1761 ()

Cocaine and other addictive drugs are known to stimulate microglia, and microglia in turn have been shown to play roles in both the development and mi......

Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure

期刊: BRAIN RESEARCH, 2021; 1767 ()

Lead (Pb) exposure damages synaptic structural plasticity that results in cognitive impairment. Resveratrol, a natural polyphenolic compound, is one o......

Effects of salvianolate lyophilized injection combined with Xueshuantong injection in regulation of BBB function in a co-culture model of endothelial cells and pericytes

期刊: BRAIN RESEARCH, 2021; 1751 ()

The combined use of two or more different drugs can better promote nerve recovery and its prognosis for treatment of stroke. The salvianolate lyophili......

The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus

期刊: BRAIN RESEARCH, 2021; 1764 ()

Status epilepticus (SE) is a neurological emergency. The pathological hallmark of neuronal damage after epileptic seizures could be the chain reaction......

Naringenin attenuates endoplasmic reticulum stress, reduces apoptosis, and improves functional recovery in experimental traumatic brain injury

期刊: BRAIN RESEARCH, 2021; 1769 ()

Traumatic brain injury (TBI) is a significant cause of disability and death worldwide. Accumulating evidence suggests that endoplasmic reticulum (ER) ......

Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy

期刊: BRAIN RESEARCH, 2021; 1764 ()

Excitation-inhibition imbalance of GABAergic interneurons is predisposed to develop chronic temporal lobe epilepsy (TLE). We have previously shown tha......

Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study

期刊: BRAIN RESEARCH, 2021; 1767 ()

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previou......

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