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Exosomes derived from stem cells from the apical papilla alleviate inflammation in rat pulpitis by upregulating regulatory T cells

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (5)

Aim To evaluate the effects of exosomes derived from stem cells from the apical papilla (SCAP-Exos) in rats with experimentally induced pulpitis and t......

JIF:4.634

Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next-generation sequencing

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (1)

Aim To determine the microorganism in root canal systems of root filled teeth with periapical disease and their relationship with clinical symptoms us......

JIF:4.634

Hsa-miRNA-143-3p regulates the odontogenic differentiation of human stem cells from the apical papilla by targeting NFIC

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (3)

Aim To evaluate the effects of hsa-miRNA-143-3p on the cytodifferentiation of human stem cells from the apical papilla (hSCAPs) and the post-transcrip......

JIF:4.634

Present status and future directions: Minimally invasive root canal preparation and periradicular surgery

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 ()

Inspired by several other surgical disciplines, the quest for treating diseases through minimally invasive procedures has permeated endodontics, but n......

JIF:4.634

The induction of inflammation by the cGAS-STING pathway in human dental pulp cells: A laboratory investigation

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (1)

Aim To explore the presence of the cGAS-STING inflammatory pathway in human pulp tissue and human dental pulp cells (HDPCs). Methodology Pulp tissue w......

JIF:4.634

Enhanced conservation of vital pulp and apical tissues by the application of crown rotation surgery for inversely impacted central incisors: A follow-up analysis of two patients over 4 years

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (8)

Aim To describe a novel surgical method (crown rotation surgery) to manage inversely impacted central incisors with immature roots. Methodology Two yo......

JIF:4.634

Chronic apical periodontitis exacerbates atherosclerosis in apolipoprotein E-deficient mice and leads to changes in the diversity of gut microbiota

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (2)

Aim To investigate the impact of chronic apical periodontitis (CAP) on atherosclerosis and gut microbiota by establishing a Porphyromonas gingivalis (......

JIF:4.634

Expression of PINK1 and Parkin in human apical periodontitis

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (8)

Aim PTEN-induced putative kinase 1 (PINK1) and Parkin E3 ubiquitin-protein ligase (Parkin) are critical for immune and inflammatory regulation in heal......

JIF:4.634

Human three-dimensional dental pulp organoid model for toxicity screening of dental materials on dental pulp cells and tissue

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (1)

Aim To establish a 3D model for screening the biocompatibility of dental materials/drugs on dental pulp cells and tissue. Methodology Human dental pul......

JIF:4.634

Effects of BMAL1 on dentinogenic differentiation of dental pulp stem cells via PI3K/Akt/mTOR pathway

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (5)

Aim This study aimed to investigate the effect of the circadian clock gene Bmal1 on dentinogenic differentiation of dental pulp stem cells (DPSCs) und......

JIF:4.634

Innate immune sensing of nucleic acid in endodontic infection

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (12)

Innate immunity is the first line of defence and fights against microorganisms. Nucleic acids are important pathogen-associated molecular patterns to ......

JIF:4.634

MicroRNA-22 suppresses NLRP3/CASP1 inflammasome pathway-mediated proinflammatory cytokine production by targeting the HIF-1 alpha and NLRP3 in human dental pulp fibroblasts

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2022; 55 (11)

Aim: To investigate the synergetic regulatory effect of miR-22 on HIF-1 alpha and NLRP3, subsequently regulating the production of the NLRP3/CASP1 inf......

JIF:4.634

Laboratory simulation of longitudinally cracked teeth using the step-stress cyclic loading method

期刊: INTERNATIONAL ENDODONTIC JOURNAL, 2021; 54 (9)

Aim To simulate in a laboratory setting longitudinal cracking in root filled premolar teeth, using cyclic mechanical fatigue. Methodology Mesial-occlu......

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