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Amine-Linked Flavonoids as Agents against Cutaneous Leishmaniasis

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids h......

Antifungal Susceptibility Profiles of Olorofim (Formerly F901318) and Currently Available Systemic Antifungals against Mold and Yeast Phases of Talaromyces marneffei

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (6)

In vitro antifungal susceptibility profiling of 32 clinical and environmental Talaromyces marneffei isolates recovered from southern China was perform......

A Yeast-Based Drug Discovery Platform To Identify Plasmodium falciparum Type II NADH Dehydrogenase Inhibitors

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (6)

Conventional methods utilizing in vitro protein activity assay or in vivo parasite survival to screen for malaria inhibitors suffer from high experime......

Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (6)

A high-throughput screen of a Roche internal chemical library based on inhibition of the respiratory syncytial virus (RSV)-induced cytopathic effect (......

Therapeutic Potential of Coumestan Pks13 Inhibitors for Tuberculosis

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

Polyketide synthase 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis that condenses two fatty acyl chains to produce alpha-alkyl ......

Identification and Characterization of Two Novel ISCR1-Associated Genes, dfrA42 and dfrA43, Encoding Trimethoprim-Resistant Dihydrofolate Reductases

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

Two novel ISCR1-associated dfr genes, dfrA42 and dfrA43, were identified from trimethoprim (TMP)-resistant Proteus strains and were shown to confer hi......

SpoT-Mediated NapA Upregulation Promotes Oxidative Stress-Induced Helicobacter pylori Biofilm Formation and Confers Multidrug Resistance

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

Recently, the incidence of drug-resistant Helicobacter pylori infection has increased. Biofilm formation confers multidrug resistance on bacteria. Mor......

A Physiologically Based Pharmacokinetic Analysis To Predict the Pharmacokinetics of Intravenous Isavuconazole in Patients with or without Hepatic Impairment

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

Isavuconazole (ISA) is an azole antifungal used in the treatment of invasive aspergillosis and mucormycosis. Patients with mild or moderate hepatic im......

RNA Interference Screening Reveals Requirement for Platelet-Derived Growth Factor Receptor Beta in Japanese Encephalitis Virus Infection

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (6)

Mosquito-borne Japanese encephalitis virus (JEV) causes serious illness worldwide and is associated with high morbidity and mortality. To identify pot......

Emergence of Two AcrB Substitutions Conferring Multidrug Resistance to Salmonella spp.

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

AcrAB-TolC is a major tripartite multidrug efflux pump conferring resistance to a wide variety of compounds in Gram-negative pathogens. Many AcrB muta......

Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

Linezolid is an oxazolidinone antibiotic exhibiting efficacy against multi-drug-resistant (MDR) Gram-positive-related infections. However, its populat......

Typing of Neisseria gonorrhoeae Isolates in Shenzhen, China, from 2014 to 2018 Reveals the Shift of Genotypes Significantly Associated with Antimicrobial Resistance

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (5)

The growing antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. Molecular typing is an ideal too......

Influence of Fluconazole Administration on Gut Microbiome, Intestinal Barrier, and Immune Response in Mice

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021; 65 (6)

Antibiotics that can treat or prevent infectious diseases play an important role in medical therapy. However, the use of antibiotics has potentially n......

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