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Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1

期刊: JOURNAL OF PATHOLOGY, 2021; 254 (5)

Distant metastasis is the major cause of colon cancer (CC) treatment failure. SAD1/UNC84 domain protein-2 (SUN2) is a key component of linker of the n......

Yes-associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice

期刊: JOURNAL OF PATHOLOGY, 2021; 255 (1)

Mounting clinical evidence has revealed that the vitamin D receptor (VDR) is associated with cholestatic liver injury, although the functions of VDR i......

Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation

期刊: JOURNAL OF PATHOLOGY, 2021; 255 (2)

Periostin is a critical extracellular regulator in the pathogenesis of liver disorders such as hepatosteatosis, non-alcoholic steatohepatitis, inflamm......

BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated beta-catenin acetylation

期刊: JOURNAL OF PATHOLOGY, 2021; 254 (3)

Chemoresistance is a major obstacle to the treatment of triple-negative breast cancer (TNBC), which has a poor prognosis. Increasing evidence has demo......

Renal deposition and clearance of recombinant poly-IgA complexes in a model of IgA nephropathy

期刊: JOURNAL OF PATHOLOGY, 2021; 254 (2)

IgA nephropathy (IgAN) is the most common type of glomerulonephritis worldwide, which follows a chronic but nonetheless highly variable course of prog......

Deletion of Sox9 in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulating Sec63

期刊: JOURNAL OF PATHOLOGY, ; ()

Hepatic cysts are found in heterogeneous disorders with different pathogeneses, of which simple hepatic cysts and polycystic liver diseases are two ma......

CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-alpha 36 axis

期刊: JOURNAL OF PATHOLOGY, ; ()

Tamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for estrogen receptor (ER)-positive breast cancer patients. Cull......

Basal microvilli define the metabolic capacity and lethal phenotype of pancreatic cancer

期刊: JOURNAL OF PATHOLOGY, 2021; 253 (3)

Apical microvilli of polarized epithelial cells govern the absorption of metabolites and the transport of fluid in tissues. Previously, we reported th......

Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells

期刊: JOURNAL OF PATHOLOGY, 2021; 253 (4)

Alcohol drinking has been established as a major risk factor for esophageal diseases. Our previous study showed that ethanol exposure inhibited PAX9 e......

Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis

期刊: JOURNAL OF PATHOLOGY, 2021; 253 (3)

The cathelin-related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation-associated carcinogenesis, and disrupted mic......

LCC18, a benzamide-linked small molecule, ameliorates IgA nephropathy in mice

期刊: JOURNAL OF PATHOLOGY, 2021; 253 (4)

IgA nephropathy (IgAN), an immune complex-mediated process and the most common primary glomerulonephritis, can progress to end-stage renal disease in ......

Immunoproteasome subunit beta 5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice

期刊: JOURNAL OF PATHOLOGY, 2020; 250 (3)

The immunoproteasome contains three catalytic subunits (beta 1i, beta 2i and beta 5i) that are important modulators of immune cell homeostasis. A prev......

Angioimmunoblastic T-cell lymphoma contains multiple clonal T-cell populations derived from a common TET2 mutant progenitor cell

期刊: JOURNAL OF PATHOLOGY, 2020; 250 (3)

Angioimmunoblastic T-cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations sugg......

Negative regulation of dendritic cell activation in psoriasis mediated via CD100-plexin-B2

期刊: JOURNAL OF PATHOLOGY, 2020; 250 (4)

Psoriasis is a chronic inflammatory skin disease in which dendritic cells (DCs) play a pivotal role by inducing Th1/Th17 immune responses; however, th......

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