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ER-mitochondrial contact protein Miga regulates autophagy through Atg14 and Uvrag

期刊: CELL REPORTS, 2022; 41 (5)

Mitochondrial malfunction and autophagy defects are often concurrent phenomena associated with neuro-degeneration. We show that Miga, a mitochondrial ......

JIF:8.695

Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state

期刊: CELL REPORTS, 2022; 41 (6)

Steady-state extramedullary hematopoiesis during adulthood is an emerging field of great interest. The meninges contain both innate and adaptive immun......

JIF:8.695

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

期刊: CELL REPORTS, 2022; 41 (8)

Branched-chain amino acid (BCAA) catabolism is related to tumorigenesis. However, the underlying mechanism and specific contexts in which BCAAs affect......

JIF:8.695

NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice

期刊: CELL REPORTS, 2022; 41 (10)

Neuroligins (NLs), a family of postsynaptic cell-adhesion molecules, have been associated with autism spec-trum disorder. We have reported that dysfun......

JIF:8.695

Acetylation-dependent regulation of BRAF oncogenic function

期刊: CELL REPORTS, 2022; 38 (3)

Aberrant BRAF activation, including the BRAF(V600E) mutation, is frequently observed in human cancers. However, it remains largely elusive whether oth......

JIF:8.695

Brown adipose tissue involution associated with progressive restriction in progenitor competence

期刊: CELL REPORTS, 2022; 39 (2)

Human brown adipose tissue (BAT) undergoes progressive involution. This involution process is not recapitulated in rodents, and the underlying mechani......

JIF:8.695

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1

期刊: CELL REPORTS, 2022; 40 (3)

R loops occur frequently in genomes and contribute to fundamental biological processes at multiple levels. Consequently, understanding the molecular a......

JIF:8.695

S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

期刊: CELL REPORTS, 2022; 40 (7)

Sorafenib is currently the first-line treatment for advanced hepatocellular carcinoma (HCC). However, sora-fenib resistance remains a significant chal......

JIF:8.695

OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased

期刊: CELL REPORTS, 2022; 41 (4)

Oral and esophageal squamous cell carcinomas (SCCs) are associated with high mortality, yet the molecular mechanisms underlying these malignancies are......

JIF:8.695

Identification and characterization of NFATc1+skeletal stem cells in bone regeneration

期刊: CELL REPORTS, 2022; 41 (6)

Skeletal stem cells (SSCs) fuel adult bone with stemness resources to maintain homeostasis and support regeneration, which depends on the precise dete......

JIF:8.695

Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis

期刊: CELL REPORTS, 2022; 41 (11)

Intestinal epithelial replenishment is fueled by continuously dividing intestinal stem cells (ISCs) resident at the crypt niche. However, the cell typ......

JIF:8.695

Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction

期刊: CELL REPORTS, 2022; 38 (7)

Tumor physical microenvironment contributes greatly to the response of tumor cells. However, the mechanism of how extracellular substrate rigidity rem......

JIF:8.695

Feedback loop promotes sucrose accumulation in cotyledons to facilitate sugar-ethylene signaling-mediated, etiolated-seedling greening

期刊: CELL REPORTS, 2022; 38 (11)

De-etiolation is indispensable for seedling survival and development. However, how sugars regulate de -etiolation and how sugars induce ethylene (ET) ......

JIF:8.695

Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers

期刊: CELL REPORTS, 2022; 40 (9)

The Hippo tumor-suppressor pathway is frequently dysregulated in human cancers and represents a thera-peutic target. However, strategies targeting the......

JIF:8.695

Uncovering the extensive trade-off between adaptive evolution and disease susceptibility

期刊: CELL REPORTS, 2022; 40 (11)

Favored mutations in the human genome may make the carriers adapt to changing environments and lifestyles but also susceptible to specific diseases. T......

JIF:8.695

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