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Activin A activation drives renal fibrosis through the STAT3 signaling pathway

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 134 ()

The present study investigated whether TGF-?1 promotes fibrotic changes in HK-2 cells through the Activin A and STAT3 signaling pathways in vitro. Bio......

The biology of combination immunotherapy in recurrent metastatic head and neck cancer

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 136 ()

Preclinical data suggest that head and neck cancer is an intrinsically immunosuppressive disease with abnormal inflammatory components in the tumor mi......

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 136 ()

Background: CD137 signaling is an essential factor in cell fate and atherosclerosis. An increase in the number of apoptotic macrophages accelerates at......

Splenectomy provides protective effects against CLP-induced sepsis by reducing TRegs and PD-1/PD-L1 expression

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 136 ()

The role of the spleen in sepsis is still controversial. Therefore, we investigated the effect of the spleen on sepsisinduced immune dysfunction in C5......

The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 135 ()

The hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are dioxygenases using oxygen and 2-oxoglutarate as co-substrates. Under normoxia, PHDs ......

MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 135 ()

Early diagnosis and precise monitoring of the development of proliferative diabetic retinopathy (PDR) can significantly improve therapeutic strategies......

Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 134 ()

Ferroptosis, a newly iron-dependent form of cell death, is often accompanied by the damage of membrane lipid peroxide. Recently, the ferroptosis induc......

HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 136 ()

High-risk human papillomavirus (HR-HPV) infection is a major risk factor for the initiation and progression of cervical cancer (CC). This study aimed ......

SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 134 ()

Introduction: SIRT4 is a mitochondrial sirtuin. Owing to its dependance on the cofactor nicotinamide adenine dinucleotide (NAD+), SIRT4 can act as a m......

JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 138 ()

Increased stemness is causally linked to development of drug resistance in cancers. JARID2 is a member of the Jumonji family of proteins and regulates......

HDAC3 increases HMGB3 expression to facilitate the immune escape of breast cancer cells via down-regulating microRNA-130a-3p

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 135 ()

Objective: Histone deacetylase 3 (HDAC3) has been reported to repress the expression of various genes by eliminating acetyl group from histone. The ob......

SNF5 promotes IL-1 beta expression via H3K4me1 in atherosclerosis induced by homocysteine

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 135 ()

Homocysteine (Hcy) is a strong and independent risk factor of atherosclerosis. It can accelerate atherosclerosis through increased production of infla......

linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021; 136 ()

Evidence shows that long noncoding RNAs (lncRNAs) modulate mRNAs of multiple genes by post-transcriptional regulation. However, in esophageal squamous......

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