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CRISPR-Cas9 gene editing induced complex on-target outcomes in human cells

期刊: EXPERIMENTAL HEMATOLOGY, 2022; 110 ()

CRISPR-Cas9 is a powerful tool for editing the genome and holds great promise for gene therapy applications. Initial concerns of gene engineering focu......

JIF:2.685

Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance

期刊: EXPERIMENTAL HEMATOLOGY, 2022; 105 ()

Acute myeloid leukemia (AML) remains a clinical challenge. Venetoclax is an effective Bcl-2 selective inhibitor approved by the U.S. Food and Drug Adm......

JIF:2.685

hnRNPK/Beclin1 signaling regulates autophagy to promote imatinib resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia cells

期刊: EXPERIMENTAL HEMATOLOGY, 2022; 108 ()

This study sought to clarify the role of heterogeneous nuclear ribonucleoprotein K (hnRNPK) as a regulator of imatinib resistance in Philadelphia chro......

JIF:2.685

The regulation roles of Ca2+ in erythropoiesis: What have we learned?

期刊: EXPERIMENTAL HEMATOLOGY, 2022; 106 ()

Calcium (Ca2+) is an important second messenger molecule in the body, regulating cell cycle and fate. There is growing evidence that intracellular Ca2......

JIF:2.685

5-Aza-dC promotes T-cell acute lymphoblastic leukemia cell invasion via downregulation of DNMT1 and upregulation of MMP-2 and MMP-9

期刊: EXPERIMENTAL HEMATOLOGY, 2022; 114 ()

5-Aza-20-deoxycytidine (5-Aza-dC) is a demethylation agent known to deplete DNA methyltransferases (DNMTs) in leukemia cancer cells, and can restore t......

JIF:2.685

TLR7/8 agonist treatment induces an increase in bone marrow resident dendritic cells and hematopoietic progenitor expansion and mobilization

期刊: EXPERIMENTAL HEMATOLOGY, 2021; 96 ()

There is accumulating evidence suggesting that toll-like receptor (TLR) signals play an important role in the regulation of hematopoietic stem/progeni......

Optimized clinical application of minimal residual disease in acute myeloid leukemia with RUNX1-RUNX1T1

期刊: EXPERIMENTAL HEMATOLOGY, 2021; 96 ()

Minimal residual disease (MRD) levels monitored by polymerase chain reaction are associated with outcomes in acute myeloid leukemia with RUNX1-RUNX1T1......

Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond?Blackfan anemia

期刊: EXPERIMENTAL HEMATOLOGY, 2021; 97 ()

Rpl11 haploinsufficient mice develop a macrocytic anemia similar to patients with DBA. Here, we fully characterize this model from clinical and pathop......

Salvianolic acid A inhibits the growth of diffuse large B-cell lymphoma through MAPK pathways

期刊: EXPERIMENTAL HEMATOLOGY, 2021; 94 ()

Treatment options are limited in patients with diffuse large B-cell lymphoma (DLBCL). Salvianolic acid A (SAA) is a water-soluble phenolic acid extrac......

Role of Apg-1 in HSF1 activation and bortezomib sensitivity in myeloma cells

期刊: EXPERIMENTAL HEMATOLOGY, 2020; 81 ()

Exposure of cells to bortezomib (BTZ) could activate heat shock protein (HSP) expression, which is regulated mainly by heat shock factor 1 (HSF1). We ......

Standardization of BCR-ABL1 quantification on the international scale in China using locally developed secondary reference panels

期刊: EXPERIMENTAL HEMATOLOGY, 2020; 81 ()

For patients with chronic myeloid leukemia, reverse transcription quantitative polymerase chain reaction is widely used in laboratories to quantify BC......

Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions

期刊: EXPERIMENTAL HEMATOLOGY, 2020; 82 ()

The histone lysine demethylase KDM5 family is implicated in normal development and stem cell maintenance by epigenetic modulation of histone methylati......

Lightening the way of hematopoiesis: Infrared laser-mediated lineage tracing with high spatial-temporal resolution

期刊: EXPERIMENTAL HEMATOLOGY, 2020; 85 ()

Hematopoiesis refers to the developmental process generating all blood lineages. In vertebrates, there are multiple waves of hematopoiesis, which emer......

Sirolimus is effective for primary relapsed/refractory autoimmune cytopenia: a multicenter study

期刊: EXPERIMENTAL HEMATOLOGY, 2020; 89 ()

Autoimmune cytopenia includes autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and Evans syndrome (ES) caused by abnormal activation......

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