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Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes

期刊: CLINICAL PHARMACOKINETICS, 2021; 60 (5)

Drug metabolism is a critical process for the removal of unwanted substances from the body. In humans, approximately 80% of oxidative metabolism and a......

Clinical Impact of the Adaptation of Initial Tacrolimus Dosing to the CYP3A5 Genotype After Kidney Transplantation: Systematic Review and Meta-Analysis of Randomized Controlled Trials

期刊: CLINICAL PHARMACOKINETICS, ; ()

Objective The aim of this systematic review and meta-analysis was to compare the clinical outcomes between genotype-guided and conventional tacrolimus......

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Cardiac Output and Its Distribution to Different Organs during Development

期刊: CLINICAL PHARMACOKINETICS, ; ()

Background and Objective Fetal circulation is unique and the parameters describing hemodynamic status during development are critical for constructing......

Pharmacokinetics and Exposure-Response Relationship of Teprotumumab, an Insulin-Like Growth Factor-1 Receptor-Blocking Antibody, in Thyroid Eye Disease

期刊: CLINICAL PHARMACOKINETICS, ; ()

Background and Objective Thyroid eye disease (TED) is characterized by inflammation/expansion of orbital tissues, proptosis, and diplopia. Teprotumuma......

Population Pharmacokinetics of Levetiracetam: A Systematic Review

期刊: CLINICAL PHARMACOKINETICS, 2021; 60 (3)

Background: Levetiracetam has been widely used as a treatment option for different types of epilepsy in both adults and children. Because of its large......

A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building

期刊: CLINICAL PHARMACOKINETICS, 2020; 59 (4)

BackgroundDevelopmental physiology can alter pharmacotherapy in preterm populations. Because of ethical and clinical constraints in studying this vuln......

Evaluation of Therapeutic Equivalence for the Follow-On Version of Intravenously Administered Non-Biological Complex Drugs

期刊: CLINICAL PHARMACOKINETICS, 2020; 59 (8)

The interchangeability evaluation for generic drugs formulated as intravenous injections normally only requires assessments of pharmaceutical equivale......

Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine

期刊: CLINICAL PHARMACOKINETICS, 2019; 58 (4)

ObjectiveThe aim of this study was to measure and investigate correlations of lamotrigine concentrations in maternal as well as umbilical cord blood, ......

JIF:4.68

Voriconazole: A Review of Population Pharmacokinetic Analyses

期刊: CLINICAL PHARMACOKINETICS, 2019; 58 (6)

Numerous population pharmacokinetic studies on voriconazole have been conducted in recent years. This review aimed to comprehensively summarize the po......

JIF:4.68

Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population

期刊: CLINICAL PHARMACOKINETICS, 0; ()

Background Preterm neonates are usually not part of a traditional drug development programme, however they are frequently administered medicines. Deve......

Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects

期刊: CLINICAL PHARMACOKINETICS, 2019; 58 (3)

Objectives The aim of this study was to assess the pharmacokinetics (PK) and safety/tolerability of siponimod in healthy subjects when coadministered ......

JIF:4.68

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