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The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1

期刊: CARCINOGENESIS, 2021; 42 (3)

Pancreatic cancer is one of the most lethal tumors across the world with an overall 5-year survival rate of 9%, and great efforts have been devoted in......

LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma

期刊: CARCINOGENESIS, 2021; 42 (5)

Diffuse large B-cell lymphoma (DLBCL) remains to be a high aggressive and invasive malignancy with enigmatic etiology. Ectopic expression of long non-......

Implication of Ataxia-Telangiectasia-mutated kinase in epithelium-mesenchyme transition

期刊: CARCINOGENESIS, 2021; 42 (4)

Impairment of genome instability drives the development of cancer by disrupting anti-cancer barriers. Upon genotoxic insults, DNA damage responsive fa......

SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer

期刊: CARCINOGENESIS, 2021; 42 (2)

A substantial fraction of transcripts are known as long noncoding RNAs (lncRNAs), and these transcripts play pivotal roles in the development of cance......

Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells

期刊: CARCINOGENESIS, 2021; 42 (5)

Sorafenib is commonly used to treat advanced human hepatocellular carcinoma (HCC). However, clinical efficacy has been limited by drug resistance. In ......

UBE3C promotes proliferation and inhibits apoptosis by activating the beta-catenin signaling via degradation of AXIN1 in gastric cancer

期刊: CARCINOGENESIS, 2021; 42 (2)

Gastric cancer (GC) remains one of the most frequent cancers worldwide. Previous studies have shown that E3 ubiquitin ligase E3C (UBE3C) promotes the ......

microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer

期刊: CARCINOGENESIS, 2021; 42 (5)

We examined the effect of microRNA-320b (miR-320b) on tumor growth and angiogenesis in lung cancer and also determined its downstream molecular mechan......

Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2

期刊: CARCINOGENESIS, 2021; 42 (8)

This study tried to explore the molecular mechanism underlying progression of lung adenocarcinoma (LUAD) and discuss the extracellular communication b......

Apelin enhances biological functions in lung cancer A549 cells by downregulating exosomal miR-15a-5p

期刊: CARCINOGENESIS, 2021; 42 (2)

Apelin acts as a tumor promoter in multiple malignant tumors; however, its regulatory mechanism remains unclear. Previous studies have indicated that ......

B4GALNT1 promotes progression and metastasis in lung adenocarcinoma through JNK/c-Jun/Slug pathway

期刊: CARCINOGENESIS, 2021; 42 (4)

Lung adenocarcinoma (LUAD) is one of the most common types of cancer and has a low survival rate. beta-1,4-N-Acetyl galactosaminyltransferase 1 (B4GAL......

Dilemma of the differential diagnosis of hilar cholangiocarcinoma and benign diseases: a single-center retrospective study

期刊: CARCINOGENESIS, 2021; 42 (3)

Hilar cholangiocarcinoma (HCCA), which lacks specific clinical manifestations, remains very difficult to distinguish from benign disease. This distinc......

Distribution and prognostic impact of M1 macrophage on esophageal squamous cell carcinoma

期刊: CARCINOGENESIS, 2021; 42 (4)

Macrophages are a double-edged sword with potential cancer-promoting and anticancer effects. Controversy remains regarding the effect of macrophages, ......

Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression

期刊: CARCINOGENESIS, 2021; 42 (4)

Lysophosphatidic acid (LPA) and its G-protein-coupled receptors (Lpar1-Lpar6) mediate a plethora of activities associated with cancer growth and progr......

ARID3A promotes the development of colorectal cancer by upregulating AURKA

期刊: CARCINOGENESIS, 2021; 42 (4)

Colorectal cancer (CRC) is one of the most common malignant tumours, and its morbidity and mortality rates are relatively high. However, the aetiology......

Low-carbohydrate diets and the risk of pancreatic cancer: a large prospective cohort study

期刊: CARCINOGENESIS, 2021; 42 (5)

Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the......

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