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IL-27 Protects the Brain from Ischemia-Reperfusion Injury via the gp130/STAT3 Signaling Pathway

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

The occurrence of ischemia-reperfusion (I/R) injury leads to dysfunction as well as high rates of morbidity and mortality in stroke, and new effective......

Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

A decline of estrogen level leads to spatial learning and memory impairments, which mediated by hippocampus and cortex. Accumulating evidences demonst......

An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (8)

Glioma is highly lethal because of its high malignancy. Ubiquitination, a type of ubiquitin-dependent protein modification, has been reported to play ......

miR-129-5p Ameliorates Ischemic Brain Injury by Binding to SIAH1 and Activating the mTOR Signaling Pathway

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

Aberrant expression of microRNAs (miRNAs) has been linked with ischemic brain injury (IBI), but the mechanistic actions behind the associated miRNAs r......

Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (8)

Glioblastoma multiforme (GBM) is the recognized as the most aggressive brain tumor with poor prognosis and low 1-year and 5-year survival rate. The tr......

A De Novo SEMA6B Variant in a Chinese Patient with Progressive Myoclonic Epilepsy-11 and Review of the Literature

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

Progressive myoclonic epilepsy is a group of neurodegenerative diseases with complex clinical and genetic heterogeneity, which is associated with spon......

Elevation of DNA Methylation in the Promoter Regions of the Brain-Derived Neurotrophic Factor Gene is Associated with Heroin Addiction

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

To study the potential role of brain-derived neurotrophic factor (BDNF) methylation in heroin addiction, we first detected the methylation level of se......

Tenascin C Promotes Glioma Cell Malignant Behavior and Inhibits Chemosensitivity to Paclitaxel via Activation of the PI3K/AKT Signaling Pathway

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (8)

The present study aimed to detect the effect of tenascin C (TNC) on cell function and chemosensitivity to paclitaxel and phosphatidylinositol 3-kinase......

Role of circRNAs in neurodevelopment and neurodegenerative diseases

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

With the rapid development of sequencing technology, scientists have been able to study and acquire a better understanding of non-coding RNAs (ncRNAs)......

Nmnat1 Modulates Mitochondrial Oxidative Stress by Inhibiting Caspase-3 Signaling in Alzheimer's Disease

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (7)

Nigrostriatal pathway disturbance is one of the major pathogenic factors in Alzheimer's disease (AD). Dopaminergic neuron dysfunction results in brady......

CircUBQLN1 Promotes Proliferation but Inhibits Apoptosis and Oxidative Stress of Hippocampal Neurons in Epilepsy via the miR-155-Mediated SOX7 Upregulation

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

Circular RNAs (circRNAs) have key roles in a variety of neurological diseases, including epilepsy. This objective of this study was to perform the fun......

Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, 2021; 71 (9)

As the key organ that separates humans from nonhuman primates, the brain has continuously evolved to adapt to environmental and climatic changes. Alth......

Molecular Characteristics of Thalamic Gliomas in Adults

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, ; ()

The 2016 World Health Organization classification of central nervous system tumor firstly introduces molecular diagnosis to glioma, while the molecula......

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I

期刊: JOURNAL OF MOLECULAR NEUROSCIENCE, ; ()

Hippocampal sclerosis (HS) is one of the most prevalent pathological types of temporal lobe epilepsy (TLE), and it significantly affects patient progn......

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