期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021; 110 (2)
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral loads change rapidly following symptom onset, so to assess antivirals it is importa......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021; 110 (2)
The objective of this study was to determine the effects of the OATP inhibitor rifampin on pharmacokinetic of Biopharmaceutics Drug Disposition Classi......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021; 110 (2)
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidel......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, ; ()
The pharmacokinetics (PK) of RO7049389, a new hepatitis B virus (HBV) core protein allosteric modulator of class I, and of its active metabolite M5 we......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, ; ()
Overexpression of AKR1C3, an aldo-keto reductase, was recently discovered in liver cancers. In this study, an inverse correlation between AKR1C3 expre......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, ; ()
Atrasentan, an endothelin receptor antagonist, showed clinically significant albuminuria reduction with minimal signs of fluid retention in phase II t......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021; 109 (4)
The pharmacokinetics (PK) of RO7049389, a new hepatitis B virus (HBV) core protein allosteric modulator of class I, and of its active metabolite M5 we......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020; 108 (3)
Propranolol suppresses tumor growth in a variety of preclinical solid tumor models, with a number of proposed cell signaling and immunological mechani......
期刊： CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020; 107 (6)
Drug safety is a severe clinical pharmacology and toxicology problem that has caused immense medical and social burdens every year. Regretfully, a rep......
