期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (1)
Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, c......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (1)
The global spread of antibiotic resistance among important human pathogens emphasizes the need to find new antibacterial drugs with a novel mode of ac......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
Identifying drug modes of action (MoA) is of paramount importance for having a good grasp of drug indications in clinical tests. Anticipating MoA can ......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
Drug-induced liver injury (DILI) is one of the major causes of drug attrition and failure. Currently, there is increasing evidence that direct inhibit......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
Copy number alteration (CNA) represents an important class of genetic variations that may contribute to tumorigenesis, tumor growth and metastatic spr......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
Tankyrases (TNKS), key transmitters in the Wnt signaling pathway which is very conservative in evolution, are vital targets as they are overexpressed ......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
As a serotonin-norepinephrine reuptake inhibitor [SNRI], venlafaxine is one of the most commonly prescribed clinical antidepressants, with a broad ran......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (2)
The transcription factor forkhead box O1 (FOXO1) negatively regulates activated EGFR signaling by turning on the gene expression of tumor suppressor K......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
Bradyrhizobium diazoefficiens is a rhizobium able to convert atmospheric nitrogen into ammonium by establishing mutualistic symbiosis with soybean. It......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
In order to elucidate the effect of flexible linker length on the catalytic efficiency of fusion proteins, two short flexible peptide linkers of vario......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
Essential genes are required for the viability of an organism. Accurate and rapid identification of new essential genes is of substantial theoretical ......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
Accurately predicting the survival outcome of patients is of great importance in clinical cancer research. In the past decade, building survival predi......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (3)
The aim of this study is to investigate the anti-angiogenic properties of andrographolide derivatives AGP-26a (12 beta-isomer), AGP-26b (12 alpha-isom......
期刊： MOLECULAR BIOSYSTEMS, 2017; 13 (4)
Enhancers are cis-acting elements that play major roles in upregulating eukaryotic gene expression by providing binding sites for transcription factor......
