期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 36 ()
Isocitrate dehydrogenase (IDH) is one key rate-limiting enzyme in the tricarboxylic acid cycle, which is related to various cancers. Tomatillo (Physal......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 38 ()
Valine-containing protein (VCP) is a member of the adenosine triphosphate family involved in a variety of cellular activities. VCP/p97 is capable of m......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 38 ()
Six new cembrane-type diterpenoids, namely ximaoglaucumins A-F (1?6), along with fifteen known related ones (7?10 and 14?24), have been isolated from ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 38 ()
Protein-protein interactions (PPIs) are essentially fundamental to all cellular processes, so that developing small molecule inhibitors of PPIs have g......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 39 ()
Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematologic cancers. We used the BRD4 inhibitor compound 13 as a le......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 41 ()
Hypoxia is one of the unique features of tumor physiology. Hypoxia inducible factor (HIF-1 alpha), as a major transcription factor in response to hypo......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 42 ()
Covalent target modulation with small molecules has been emerging as a promising strategy for drug discovery. However, covalent inhibitory antibody re......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 43 ()
In order to find new and highly effective anti-tumor drugs with targeted therapeutic effects, a series of novel 4aminoquinazoline derivatives containi......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 40 ()
Ascaphin-8 is an ?-helical anti-tumor and antimicrobial peptide containing 19 residues, which was isolated from norepinephrine-stimulated skin secreti......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 36 ()
HBV capsid assembly has been regarded as an attractive potential target for anti-HBV therapy. In this study, we discovery the Novel HBV capsid assembl......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 42 ()
To further explore the chemical space surrounding the "hydrophobic channel" of the NNRTI binding pocket (NNIBP), a new series of diarylpyrimidines (DA......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 38 ()
Xanthine oxidase is the rate-limiting enzyme critical for the synthesis of uric acid, and therefore xanthine oxidase inhibitors are considered as one ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 43 ()
The farnesoid X receptor (FXR) is a promising therapeutic target for nonalcoholic steatohepatitis (NASH) and other bile acid related diseases because ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 37 ()
To address drug resistance caused by ALK kinase mutations, a series of novel 2,4-diarylaminopyrimidine (DAAP) analogues were designed by incorporating......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 37 ()
A novel series of multitargeted molecules were designed and synthesized by combining the pharmacological role of cholinesterase inhibitor and antioxid......
