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Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma

期刊: THERANOSTICS, 2021; 11 (4)

Cancer development is a complex set of proliferative progression, which arises in most cases via multistep pathways associated with various factors, i......

Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer

期刊: THERANOSTICS, 2021; 11 (13)

Background: Neoadjuvant chemotherapy is relevant to the formation of thromboembolism and secondary neoplasms in triple-negative breast cancer (TNBC). ......

Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities

期刊: THERANOSTICS, 2021; 11 (17)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to have higher pathogenicity among patients with obesity. Obesity, termed as body......

Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

期刊: THERANOSTICS, 2021; 11 (6)

Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are......

CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors

期刊: THERANOSTICS, 2021; 11 (15)

Background: Homologous recombination deficiency (HRD) is a common molecular characteristic of genomic instability, and has been proven to be a biomark......

NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation

期刊: THERANOSTICS, 2021; 11 (5)

Rationale: Inflammatory stimuli from the tumor microenvironment play important roles in cancer progression. However, the mechanism of promotion of can......

KAT6A, a novel regulator of beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

期刊: THERANOSTICS, 2021; 11 (13)

Background: Ovarian cancer is a fatal gynecologic malignancy that is found worldwide and exhibits an insidious onset and a lack of early warning sympt......

Neoantigen landscape in metastatic nasopharyngeal carcinoma

期刊: THERANOSTICS, 2021; 11 (13)

Background: Reportedly, nasopharyngeal carcinoma (NPC) patients with MHC I Class aberration are prone to poor survival outcomes, which indicates that ......

Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin

期刊: THERANOSTICS, 2021; 11 (13)

Vascular endothelial cells (ECs) are increasingly recognized as active players in intercellular crosstalk more than passive linings of a conduit for n......

Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation

期刊: THERANOSTICS, 2021; 11 (4)

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating cancers without effective treatments. Amplified in b......

Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice

期刊: THERANOSTICS, 2021; 11 (8)

Rationale: Mechanisms underlying the compromised bone formation in type 1 diabetes mellitus (T1DM), which causes bone fragility and frequent fractures......

Deuterium oxide as a contrast medium for real-time MRI-guided endovascular neurointervention

期刊: THERANOSTICS, 2021; 11 (13)

Rationale: Endovascular intervention plays an important role in the treatment of various diseases, in which MRI-guidance can potentially improve preci......

Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy

期刊: THERANOSTICS, 2021; 11 (12)

Carrier-free prodrug-nanoassemblies have emerged as promising nanomedicines. In particular, the self-assembled nanoparticles (NPs) composed of homodim......

Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma

期刊: THERANOSTICS, 2021; 11 (6)

Traumatic brain injury (TBI) is a sudden injury to the brain, accompanied by the production of large amounts of reactive oxygen and nitrogen species (......

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