期刊： NATURE BIOTECHNOLOGY, 2022; 40 (2)
Optogenetic technologies have transformed our ability to precisely control biological processes in time and space. Yet, current eukaryotic optogenetic......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (4)
A main determinant of the spatial resolution of live-cell super-resolution (SR) microscopes is the maximum photon flux that can be collected. To furth......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (10)
Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets inc......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (11)
High-resolution optical imaging deep in tissues is challenging because of optical aberrations and scattering of light caused by the complex structure ......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (5)
Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a wide range of physiological processes, but their in vivo dynamics......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (5)
Photoswitchable RNA-binding proteins enable the spatiotemporal control of RNA function. RNA-binding proteins (RBPs) play an essential role in regulati......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (8)
Deep learning analysis of microscopy and spatial transcriptomics data characterizes cell types and states. Spatial transcriptomics enables the simulta......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (11)
A new study describes a microscope combining three-photon excitation and adaptive optics capable of high-resolution in vivo imaging of fine neuronal s......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (9)
Prime editing is a versatile genome-editing technology, but it suffers from low editing efficiency. In the present study, we introduce optimized prime......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (9)
Crop genetic improvement requires balancing complex tradeoffs caused by gene pleiotropy and linkage drags, as exemplified by IPA1 (Ideal Plant Archite......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (11)
Mirror-image aptamers made from chirally inverted nucleic acids are nuclease-resistant and exceptionally biostable, opening up opportunities for uniqu......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (9)
The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes ......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (9)
Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-l......
期刊： NATURE BIOTECHNOLOGY, 2022; 40 (8)
Functional studies of the RNA N-6-methyladenosine (m(6)A) modification have been limited by an inability to map individual m(6)A-modified sites in who......
