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Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation

期刊: IMMUNOLOGY, 2021; 164 (2)

Allergic diseases are caused by dysregulated Th2 immune responses involving multiple effector cells including basophils. Short chain fatty acids (SCFA......

Emerging roles of extracellular vesicles in COVID-19, a double-edged sword?

期刊: IMMUNOLOGY, 2021; 163 (4)

The sudden outbreak of SARS-CoV-2-infected disease (COVID-19), initiated from Wuhan, China, has rapidly grown into a global pandemic. Emerging evidenc......

Neutralizing interferon-alpha blocks inflammation-mediated vascular injury via PI3K and AMPK in systemic lupus erythematosus

期刊: IMMUNOLOGY, 2021; 164 (2)

Plasmacytoid dendritic cells (pDCs) play a key role in the initiation and amplification of systemic lupus erythematosus (SLE)-associated vascular inju......

Dual effect of IL-7/IL-7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis

期刊: IMMUNOLOGY, 2021; 164 (1)

The IL-7/IL-7R pathway plays a vital role in the immune system, especially in the inflammatory response. Monocytes/macrophages (osteoclast precursors)......

Gm40600 promotes CD4(+) T-cell responses by interacting with Ahnak

期刊: IMMUNOLOGY, 2021; 164 (1)

It is important to characterize novel proteins involved in T- and B-cell responses. Our previous study demonstrated that a novel protein, Mus musculus......

CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation

期刊: IMMUNOLOGY, 2021; 164 (1)

CD11c is a canonical dendritic cell (DC) marker with poorly defined functions in the immune system. Here, we found that blocking CD11c on human periph......

Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination

期刊: IMMUNOLOGY, 2021; 164 (1)

Intravenous immunoglobulin (IVIG) is an established treatment for numerous autoimmune conditions. Although Fc fragments derived from IVIG have shown e......

FcRn is not the receptor mediating the transfer of serum IgG to colostrum in pigs

期刊: IMMUNOLOGY, 2021; 163 (4)

In contrast to humans or rabbits, in which maternal IgG is transmitted to offspring prenatally via the placenta or the yolk sac, large domestic animal......

Biological functions of IL-17-producing cells in mycoplasma respiratory infection

期刊: IMMUNOLOGY, 2021; 164 (2)

Mycoplasmas are the smallest and simplest bacteria that lack a cell wall but have the capability of self-replication. Among them, Mycoplasma pneumonia......

PTBP1 is necessary for dendritic cells to regulate T-cell homeostasis and antitumour immunity

期刊: IMMUNOLOGY, ; ()

Dendritic cells (DCs) play an important role in linking innate and adaptive immunity. DCs can sense endogenous and exogenous antigens and present thos......

Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3

期刊: IMMUNOLOGY, ; ()

Interferon regulatory factor 3 (IRF3) is a critical transcription factor for inducing production of type I interferons (IFN-I) and regulating host ant......

Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model

期刊: IMMUNOLOGY, ; ()

Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotriene receptor (C......

Epithelial cell-derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T-cell differentiation

期刊: IMMUNOLOGY, ; ()

The mechanism of generation of regulatory T cells (Treg) remains incompletely understood. Recent studies show that CD83 has immune regulatory function......

LincRNA-EPS alleviates severe acute pancreatitis by suppressing HMGB1-triggered inflammation in pancreatic macrophages

期刊: IMMUNOLOGY, ; ()

Acute pancreatitis (AP), an inflammatory disorder of the pancreas with a high hospitalization rate, frequently leads to systemic inflammatory response......

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