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Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1 alpha Downregulation for Tumor Treatment

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (5)

The overexpression of HIF-1 alpha in solid tumors due to hypoxia is closely related to drug resistance and consequent treatment failure. Herein, we co......

Pioneering Iodine-125-Labeled Nanoscale Covalent Organic Frameworks for Brachytherapy

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (4)

Brachytherapy has been clinically used for the treatment of malignant solid tumors. However, the classic therapeutic radioactive I-125 seed must be su......

General Method for Post-Synthetic Modification of Oligonucleotides Based on Oxidative Amination of 4-Thio-2 '-deoxyuridine

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (4)

Functionalized oligonucleotides (ONs) are widely applied as target binding molecules for biosensing and regulators for gene expression. Numerous effor......

Spherical Nucleic Acid Mediated Functionalization of Polydopamine-Coated Nanoparticles for Selective DNA Extraction and Detection

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (4)

Magnetic nanoparticles have been widely used for the separation of biomolecules for biological applications due to the mild and efficient separation p......

Polymeric RNAi Constructs Tailored with Appreciable Transcellular Trafficking Functions for Potential Suppression of Parathyroid Hormone Production

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (5)

Polymeric small interfering RNA (siRNA) conjugate was elaborated to sequentially circumvent the predefined biological barriers encountered in the jour......

Cyclotriphosphazene-Based "Butterfly" Fluorescence Probe for Lysosome Targeting

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (6)

A cyclotriphosphazene-based "butterfly" fluorescence probe HCCP-MNI bearing two naphthalimide and morpholine units were developed for lysosome targeti......

Bioresorbable Depot for Sustained Release of Immunostimulatory Resiquimod in Suppressing Both Primary Triple-Negative Breast Tumors and Metastatic Occurrence

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (5)

In light of immune facilities trafficking toward the pathological sites along upward gradient of immunostimulatory cytokines, a localized resiquimod (......

Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (4)

As dental implants have become one of the main treatment options for patients with tooth loss, the number of patients with peri-implant diseases has i......

Cysteine-Based Coupling: Challenges and Solutions

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (8)

Antibody-drug conjugates (ADCs) have attracted great attention in recent years in the wake of an accelerated FDA approval rate and several large-scale......

At-211-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (8)

Targeted radionuclide therapy (TRT) provides new and safe opportunities for cancer treatment and management with high precision and efficiency. Here w......

Overcoming Tumor Hypoxia through Multiple Pathways Using an All-in-One Polymeric Therapeutic Agent to Enhance Synergistic Cancer Photo/Chemotherapy Effects

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (8)

Hypoxia is a significant characteristic of tumors, which causes aggressive tumor growth and strong therapy resistance. Inspired by the improved therap......

Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (5)

SARS-CoV-2 caused the COVID-19 pandemic that lasted for more than a year. Globally, there is an urgent need to use safe and effective vaccines for imm......

A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (6)

Antibody-drug conjugates (ADCs) are complex pharmaceutical molecules that combine monoclonal antibodies with biologically active drugs through chemica......

GB Tags: Small Covalent Peptide Tags Based on Protein Fragment Reconstitution

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (8)

Developing peptide tags that can bind target proteins covalently under mild conditions is of great importance for a myriad of applications, ranging fr......

C-S Coupling of DNA-Conjugated Aryl Iodides for DNA-Encoded Chemical Library Synthesis

期刊: BIOCONJUGATE CHEMISTRY, 2021; 32 (4)

Thioethers have been widely found in biologically active compounds, including pharmaceuticals. In this report, a highly efficient approach to on-DNA c......

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