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Pterostilbene inhibits hepatocellular carcinoma proliferation and HBV replication by targeting ribonucleotide reductase M2 protein

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

Hepatocellular carcinoma (HCC), one of the most deadly diseases all around the world. HBV infection is a causative factor of HCC and closely associate......

Screening and diagnosis of colorectal cancer and advanced adenoma by Bionic Glycome method and machine learning

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

Colorectal cancer (CRC), one of the major health problems worldwide, mostly develops from colorectal adenomas. Advanced adenomas are generally conside......

Development and validation of survival nomograms in colorectal cancer patients with synchronous liver metastases underwent simultaneous surgical treatment of primary and metastatic lesions

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

Colorectal cancer patients with synchronous liver metastases (CRSLM) can be treated by simultaneous surgery, that is the primary tumor and liver metas......

Extracellular vesicles in Inter-Kingdom communication in gastrointestinal cancer

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (4)

The production and secretion of extracellular vesicles (EVs) are common features of cells (including various normal cells, neoplastic cell lines as we......

A therapeutic approach with combination of interferon-gamma and autophagy inhibitor for oral squamous cell carcinoma

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (4)

Former clinical trials and experimental research have indicated that Interferon-gamma therapy does not achieve an ideal effect in solid tumors. Autoph......

Deciphering the performance of polo-like kinase 1 in triple-negative breast cancer progression according to the centromere protein U-phosphorylation pathway

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (5)

In general, the lack of effective therapeutic targets has led to the poor prognosis of triple-negative breast cancer (TNBC). Polo-like kinase 1 (PLK1)......

Contemporary external beam radiotherapy boost or high dose-rate brachytherapy boost for cervical cancer: a propensity-score-matched, nationwide, population-based cohort study

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (4)

To estimate the survival effects of contemporary external beam radiotherapy (EBRT) boost modalities (intensity-modulated radiation therapy or volumetr......

CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (3)

Breast cancer is the leading cause of cancer-related deaths in women worldwide. Several studies have indicated that abnormal chondroitin sulfate (CS) ......

Establishment and verification of prognostic model for gastric cancer based on autophagy-related genes

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (4)

Autophagy played a significant role in the development of cancer. In this study, we explored the value of autophagy-associated genes in gastric cancer......

Targeting ERK combined with apatinib may be a promising therapeutic strategy for treating oral squamous cell carcinoma

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

Apatinib is an oral tyrosine kinase inhibitor that targets VEGFR2 signaling and shows potent antitumor effects in various cancers. In this study, we e......

Quantitative evaluation and comparison of two prodrug-activating suicide gene therapies on oral squamous cell carcinoma

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (4)

Prodrug-activating suicide gene therapy (PA suicide gene therapy for short) for cancer is to introduce cancer cells with suicide genes. The enzyme enc......

Epigenetic heterogeneity promotes acquired resistance to BET bromodomain inhibition in ovarian cancer

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

BET bromodomain inhibitors (BETi) are promising therapeutic regimens for epithelial ovarian cancer (EOC). However, early-stage clinical trials indicat......

Regional lymph nodes distribution pattern in central area of right-sided colon cancer: in-vivo detection and the update on the clinical exploration

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (5)

Distribution of regional lymph nodes (LNs) is decisive for the lymphadenectomy boundary in radical resection of right-sided colon cancer (RCC). Curren......

Roles of long noncoding RNAs on tumor immune escape by regulating immune cells differentiation and function

期刊: AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (6)

A long noncoding RNA (lncRNA) transcript is generally more than 200 nucleotides in length and rarely codes for any protein. Currently, many lncRNAs ha......

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