Neuron-restrictive silencing factor (NRSF) is a zinc-finger transcription factor that regulates expression of a diverse set of genes. However, NRSF fu......
Sodium salicylate, one of the non-steroidal anti-inflammatory drugs, is widely prescribed in the clinic, but a high dose of usage can cause hyperactiv......
It is well known that distributed learning (DL) leads to improved memory performance compared with massed learning (ML) (i.e., spacing effect). Howeve......
When new information is relevant to prior knowledge or schema, it can be learned and remembered better. Rodent studies have suggested that the hippoca......
The importance of the hippocampus in spatial learning is well established, but the precise relative contributions by the dorsal (septal) and ventral (......
期刊: HIPPOCAMPUS, 2020; 30 (10)
Changes in the expression of HCN ion channels leading to changes inI(h)function and neuronal excitability are considered to be possible mechanisms inv......
期刊: HIPPOCAMPUS, 2020; 30 (12)
Although the function of the hippocampus and adjacent medial temporal lobe (MTL) areas in forming associations is generally recognized, how MTL contri......
期刊: HIPPOCAMPUS, 2019; 29 (11)
The early postnatal stage is a critical period of hippocampal neurodevelopment and also a period of high vulnerability to adverse life experiences. Re......
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest a......
期刊: HIPPOCAMPUS, 2018; 28 (11)
There is growing evidence for dysfunctional glutamatergic excitation and/or gamma-aminobutyric acid (GABA)ergic inhibition in patients with multiple s......
Type 2 diabetes mellitus (T2DM) is an important risk factor for Alzheimer's disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insuli......
Amyloid protein (A) plays a critical role in pathogenesis of Alzheimer's disease (AD). Our previous studies indicated that the sequence 31-35 in A mol......
By acting on serotonin 5-HT2A receptors (5-HT(2A)Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neurona......
期刊: HIPPOCAMPUS, 2017; 27 (12)
Adult neurogenesis and synaptic remodeling persist as a unique form of structural and functional plasticity in the hippocampal dentate gyrus (DG) and ......
期刊: HIPPOCAMPUS, 2017; 27 (11)
A unique topographical representation of space is found in the concerted activity of grid cells in the rodent medial entorhinal cortex. Many among the......