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Sialidase of Glaesserella parasuis Augments Inflammatory Response via Desialylation and Abrogation of Negative Regulation of Siglec-5

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Siglecs are sialic acid-binding immunoglobulin-like lectins that play an important role in tissue homeostasis, immune response, and pathogen infection......

Taurine-Mediated IDOL Contributes to Resolution of Streptococcus uberis Infection

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Metabolic alterations occur in pathogenic infections, but the role of lipid metabolism in the progression of bacterial mastitis is unclear. Cross talk......

IFN-gamma(-/-) Mice Resist Actinobacillus pleuropneumoniae Infection by Promoting Early Lung IL-18 Release and PMN-I Accumulation

期刊: INFECTION AND IMMUNITY, 2021; 89 (6)

Porcine pleuropneumonia is a common infectious disease of pigs caused by Actinobacillus pleuropneumoniae. Interferon gamma (IFN-gamma) expression incr......

mRNA Transcriptome Analysis of Bone in a Mouse Model of Implant-Associated Staphylococcus aureus Osteomyelitis

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

To investigate the molecular pathogenesis of bone with osteomyelitis, we developed implant-associated osteomyelitis (IAOM) models in mice. An orthoped......

Response of Leucine-Rich Repeat Domain-Containing Protein in Haemaphysalis longicornis to Babesia microti Infection and Its Ligand Identification

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Haemaphysalis longicornis is a blood-feeding hard tick known for transmitting a variety of pathogens, including Babesia. How the parasites in the imbi......

Increased Pulmonary Pneumococcal Clearance after Resolution of H9N2 Avian Influenza Virus Infection in Mice

期刊: INFECTION AND IMMUNITY, 2021; 89 (6)

H9N2 avian influenza virus has been continuously circulating among poultry and can infect mammals, indicating that this virus is a potential pandemic ......

The KbvR Regulator Contributes to Capsule Production, Outer Membrane Protein Biosynthesis, Antiphagocytosis, and Virulence in Klebsieila pneumoniae

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Klebsiella pneumoniae is an opportunistic pathogen that mostly affects patients with weakened immune systems, but a few serotypes (especially K1 and K......

Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-kappa B/NLRP3/IL-1 beta Pathway in Macrophages

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Trichinellosis is one of most neglected foodborne zoonoses worldwide. During Trichinella spiralis infection, the intestinal immune response is the fir......

A SNP in the Cache 1 Signaling Domain of Diguanylate Cyclase STM1987 Leads to Increased In Vivo Fitness of Invasive Salmonella Strains

期刊: INFECTION AND IMMUNITY, 2021; 89 (4)

Nontyphoidal Salmonella (NTS) strains are associated with gastroenteritis worldwide but are also the leading cause of bacterial bloodstream infections......

Polymorphonuclear Myeloid-Derived Cells That Contribute to the Immune Paralysis Are Generated in the Early Phase of Sepsis via PD-1/PD-L1 Pathway

期刊: INFECTION AND IMMUNITY, 2021; 89 (6)

Immune paralysis is a protracted state of immune suppression following the early/acute inflammatory phase of sepsis. CD11b(+) Gr-1(+) cells induced du......

In Vivo and In Vitro Impairments in T Helper Cell and Neutrophil Responses against Mucor irregularis in Card9 Knockout Mice

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Mucor irregularis is a frequently found fungus in Asia, especially China, and it causes primary cutaneous mucormycosis with a high rate of disfigureme......

Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence

期刊: INFECTION AND IMMUNITY, 2021; 89 (5)

Listeria monocytogenes is a Gram-positive, intracellular pathogen that is highly adapted to invade and replicate in the cytosol of eukaryotic cells. I......

TLR7 Expression Aggravates Invasive Pulmonary Aspergillosis by Suppressing Anti-Aspergillus Immunity of Macrophages

期刊: INFECTION AND IMMUNITY, 2021; 89 (4)

Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary ......

STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway

期刊: INFECTION AND IMMUNITY, 2021; 89 (3)

Schistosomiasis is a parasitic helminth disease that can cause organ lesions leading to health damage. During a schistosome infection, schistosome egg......

Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates

期刊: INFECTION AND IMMUNITY, 2021; 89 (3)

The lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control of tuberculosis......

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