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Single-Cell RNA-Sequencing Reveals Lineage-Specific Regulatory Changes of Fibroblasts and Vascular Endothelial Cells in Keloids

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (1)

Keloids are a benign dermal fibrotic disorder with features similar to malignant tumors. keloids remain a therapeutic challenge and lack medical thera......

JIF:4.296

MED1 Downregulation Contributes to TGFb-Induced Metastasis by Inhibiting SMAD2 Ubiquitination Degradation in Cutaneous Melanoma

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (8)

Metastasis is the main reason for the high mortality of patients and indeed a difficult task in the treatment of cutaneous melanoma. Therefore, it is ......

JIF:4.296

LPCAT1 Promotes Cutaneous Squamous Cell Carcinoma via EGFR-Mediated Protein Kinase B/p38MAPK Signaling Pathways

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (2)

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. LPCAT1, a lysophosphatidylcholine acyltransferase, takes a cen......

JIF:4.296

Increased IRF9-STAT2 Signaling Leads to Adaptive Resistance toward Targeted Therapy in Melanoma by Restraining GSDME-Dependent Pyroptosis

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (9)

Melanoma is the leading cause of cutaneous malignancy death. BRAF inhibitors (BRAFis) have been developed as target therapies because nearly half of p......

JIF:4.296

Prophylactic Effect of Nitric Oxide Donors on Rat Models of EGFR Inhibitor-Induced Cutaneous Toxicities

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (11)

EGF receptor (EGFR) inhibitors have been established as first-line standard-of-care therapies for nonsmall cell lung cancer but are frequently accompa......

JIF:4.296

N2-Polarized Neutrophils Reduce Inflammation in Rosacea by Regulating Vascular Factors and Proliferation of CD4(+) T Cells

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (7)

The infiltration of neutrophils is implicated in rosacea, which is a common chronic inflammatory facial disease. This study explores the biological fu......

JIF:4.296

LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2-NLRC4 Axis

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (8)

Lipocalins are a family of secreted adipokines that regulate cell lipid metabolism and immune responses. Although we have previously revealed that LCN......

JIF:4.296

KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (7)

Hypertrophic scar is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and ......

JIF:4.296

OPN3 Regulates Melanogenesis in Human Congenital Melanocytic Nevus Cells through Functional Interaction with BRAF(V600E)

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (11)

OPN3, as a member of the opsin family, has various nonlight-dependent functions. Congenital melanocytic nevus (CMN) is a skin lesion with dark pigment......

JIF:4.296

CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (7)

Circular RNAs have been confirmed to play vital roles in the development of human diseases. Nevertheless, their effects on modulating mesenchymal stro......

JIF:4.296

Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (8)

Psoriasis is a chronic immune-mediated skin disorder with the nervous system contributing to its pathology. The neurogenic mediators of psoriasis are ......

JIF:4.296

Quinolinic Acid, a Tryptophan Metabolite of the Skin Microbiota, Negatively Regulates NLRP3 Inflammasome AhR in Psoriasis

期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022; 142 (8)

Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves skin microbiota dysbiosis. Mul-tiple studies have revealed the changes in......

JIF:4.296

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