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The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Objective: In this post-hoc analysis, we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal......

Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: Patient-derived xenograft (PDX) models have shown great promise in preclinical and translational applications, but their consistency with p......

Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: Patients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand......

A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: To compare the efficacy and safety of hyperthermic intravesical chemotherapy (HIVEC) and intravesical chemotherapy (IVEC) in patients with ......

Biomaterial-based platforms for cancer stem cell enrichment and study

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Cancer stem cells (CSCs) are a relatively rare subpopulation of tumor cell with self-renewal and tumorigenesis capabilities. CSCs are associated with ......

Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Circular RNAs (circRNAs), a class of endogenous RNA molecules, are produced by alternative splicing of precursor RNA and are covalently linked at the ......

VEGFR2 inhibition hampers breast cancer cell proliferation via enhanced mitochondrial biogenesis

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: Vascular endothelial growth factor (VEGF), apart from its predominant roles in angiogenesis, can enhance cancer cell proliferation, but its......

BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: BYSL, which encodes the Bystin protein in humans, is upregulated in reactive astrocytes following brain damage and/or inflammation. We aime......

Circular RNAs: new biomarkers of chemoresistance in cancer

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Chemotherapeutics are validated conventional treatments for patients with advanced cancer. however, with continual application of chemotherapeutics, c......

Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Radiotherapy is one of the most effective treatment methods for various solid tumors. Bidirectional signal transduction between cancer cells and strom......

Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

The epithelial mesenchymal transition (EMT) is a highly complex phenotypic conversion during embryogenesis, and is important for metastasis, which con......

Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Objective: Natural extracts, including nobiletin, have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs. However, wheth......

Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Objective: Dysfunction in fibroblast growth factor receptor (FGFR) signaling has been reported in diverse cancer types, including non-small cell lung ......

LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (2)

Objective: Several reports have proposed that lncRNAs, as potential biomarkers, participate in the progression and growth of malignant tumors. HIF1A-A......

Competing endogenous RNAs in lung cancer

期刊: CANCER BIOLOGY & MEDICINE, 2021; 18 (1)

Competing endogenous RNAs (ceRNAs) containing microRNA response elements can competitively interact with microRNA via miRNA response elements, which c......

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