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Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos

期刊: NEOPLASMA, 2021; 68 (1)

Glioma is the most common type of brain cancer. Chemotherapy combination with surgery and radiotherapy is a standard treatment for patients. Although ......

Paired-like homeodomain transcription factor 2 strengthens chemoresistance in colorectal cancer by activating the Wnt/beta-catenin axis

期刊: NEOPLASMA, 2021; 68 (3)

The purpose of this study was to determine the mechanism of paired-like homeodomain transcription factor 2 (PITX2) in the chemoresistance of colorecta......

Downregulation of CDC20 suppressed cell proliferation, induced apoptosis, triggered cell cycle arrest in osteosarcoma cells, and enhanced chemosensitivity to cisplatin

期刊: NEOPLASMA, 2021; 68 (2)

Ostcosarcoma (OS) is a common malignant bone tumor that occurs in adolescents or children under the age of 20, which is extremely difficult to cure an......

The combination of PRL-3 inhibitor with sorafenib synergistically promotes AML apoptosis

期刊: NEOPLASMA, 2021; 68 (4)

Phosphatase of regenerating liver-3 (PRL-3) is recognized as a novel independent crucial driver for AML progression. Thus, the specific inhibitor of P......

Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis

期刊: NEOPLASMA, 2021; 68 (4)

Osteosarcoma (OS) is a lethal bone malignancy. Circular RNAs (circRNAs) have emerged as important regulators of OS development. CircRNA cyclin depende......

microRNA-204 shuttled by mesenchymal stem cell-derived exosomes inhibits the migration and invasion of non-small-cell lung cancer cells via the KLF7/AKT/HIF-1 alpha axis

期刊: NEOPLASMA, 2021; 68 (4)

Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death worldwide. Accumulating researches have highlighted the ability o......

CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells

期刊: NEOPLASMA, 2021; 68 (1)

Our previous studies have illustrated that CacyBP/SIP (Calcyclin-binding protein or Siah-1-interacting protein) promoted the proliferation of glioma c......

Efficacy and safety of regorafenib or fruquintinib plus camrelizumab in patients with microsatellite stable and/or proficient mismatch repair metastatic colorectal cancer: an observational pilot study

期刊: NEOPLASMA, 2021; 68 (4)

This study was to investigate the efficacy and safety of regorafenib or fruquintinib combined with camrelizumab in patients with microsatellite stable......

Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients

期刊: NEOPLASMA, 2021; 68 (3)

CDA 435C>T is reported as a functional SNP but there is no relevant research on the efficacy/hematological toxicity of gemcitabine-platinum treatme......

PGC-1 alpha activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer

期刊: NEOPLASMA, 2021; 68 (2)

Breast cancer is the leading cause of death among women. PGC-1 alpha plays an important role in the regulation of metabolic reprogramming in cancer ce......

Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4

期刊: NEOPLASMA, 2021; 68 (1)

Ovarian cancer is the most lethal gynecological cancer. In spite of recent advances, clinical outcomes remain poor, urgently needing novel therapeutic......

The role of angiotensin-(1-7) on acquired platinum resistance-induced angiogenesis in non-small cell lung cancer in vitro and in vivo

期刊: NEOPLASMA, 2021; 68 (4)

Renin-angiotensin system (RAS) signaling has been implicated in the development of cancer. The new RAS ACE2/Ang-(1-7)/Mas axis antagonizes the classic......

DNA methylation patterns of the SOCS1 gene in peripheral blood identifies risk loci associated with bladder cancer based on principal component analysis

期刊: NEOPLASMA, 2021; 68 (3)

Bladder cancer (BCa) is a common carcinoma of the urinary tract, which occurs in the bladder mucosa. In recent years, people have recognized that epig......

Survival of cancer patients in Fujian, Southeast China: a population-based cancer registry study

期刊: NEOPLASMA, 2021; 68 (4)

Survival rates are usually used to evaluate the effect of cancer treatment and prevention. No study has focused on the characteristic of population-ba......

High expression of SH2B adaptor protein 1 (SH2B1) indicates poor prognosis in colorectal cancer

期刊: NEOPLASMA, 2021; 68 (3)

SH2B1, an adaptor protein associated with obesity, is closely related to the occurrence and development of a variety of tumors. To investigate the cli......

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