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The complete plastid genome of Cotinus coggygria and phylogenetic analysis of the Anacardiaceae

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (3)

Cotinus coggygria Scop. (Anacardiaceae) is an important ornamental tree with beautiful characteristics that is grown in China. In this study, the comp......

A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfate

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

Hereditary multiple exostoses (HME) is a rare skeletal disorder characterized by the formation of multiple benign cartilage-capped tumors, usually in ......

Role of N6-methyl-adenosine modification in mammalian embryonic development

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological......

The clinical significance and function of miR-146 in the promotion of epidural fibrosis

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

Epidural fibrosis is the main cause of failed back surgery syndrome. To investigate the role of miR-146 in the diagnosis and development of epidural f......

miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investiga......

MiR-181b serves as diagnosis and prognosis biomarker in severe community-acquired pneumonia

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (3)

Severe community-acquired pneumonia (SCAP) is a common critical disease in the intensive care unit (ICU). This study aims to evaluate the clinical sig......

EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (3)

Age-related cataract (ARC) is a progressive lens opacification that occurs from middle to old age. Eph-receptor tyrosinekinase-type A2 (EphA2) has bee......

Genetic structure of the endangered Irrawaddy dolphin (Orcaella brevirostris) in the Gulf of Thailand

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

The Irrawaddy dolphin (Orcaella brevirostris) is an endangered, small cetacean species which is widely distributed in rivers, estuaries, and coastal w......

Long noncoding RNA POU6F2-AS1 regulates lung cancer aggressiveness through sponging miR-34c-5p to modulate KCNJ4 expression

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (2)

It has been extensively reported that long noncoding RNAs (lncRNAs) were closely associated with multiple malignancies. The aim of our study was to in......

Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/beta-catenin signaling pathways

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (3)

This study aimed to elucidate the anti-inflammatory and antioxidant properties of resveratrol (RSV) in human gingival fibroblasts (HGFs) following sti......

MicroRNA-149 is downregulated in Alzheimer's disease and inhibits beta-amyloid accumulation and ameliorates neuronal viability through targeting BACE1

期刊: GENETICS AND MOLECULAR BIOLOGY, 2021; 44 (1)

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a critical role in Alzheimer's disease (AD) pathogenesis. This study aimed to inve......

A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China

期刊: GENETICS AND MOLECULAR BIOLOGY, 2020; 43 (1)

Paired basic amino acid-cleaving enzyme 4 (PACE4), a proprotein convertase, is involved in the activation of aggrecanases (ADAMTS-4 and ADAMTS-5) in o......

Identification of histone methylation modifiers and their expression patterns during somatic embryogenesis in Hevea brasiliensis

期刊: GENETICS AND MOLECULAR BIOLOGY, 2020; 43 (1)

Histone methylation plays a crucial role in various biological processes, from heterochromatin formation to transcriptional regulation. Currently, no ......

Proteomic analysis of a clavata-like phenotype mutant in Brassica napus

期刊: GENETICS AND MOLECULAR BIOLOGY, 2020; 43 (1)

Rapeseed is one of important oil crops in China. Better understanding of the regulation network of main agronomic traits of rapeseed could improve the......

Molecular characterization and transcription analysis of DNA methyltransferase genes in tomato (Solanum lycopersicum)

期刊: GENETICS AND MOLECULAR BIOLOGY, 2020; 43 (1)

DNA methylation plays an important role in plant growth and development, gene expression regulation, and maintenance of genome stability. However, onl......

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