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Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-KB signaling pathway in mice spinal cords

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 90 ()

Many studies have shown that aflatoxin B1 (AFB1) can cause cytotoxicity in numerous cells and organs induced by oxidative stress. However, the toxic e......

JIF:4.623

Repeated radon exposure induced lung damage via oxidative stress-mediated mitophagy in human bronchial epithelial cells and mice

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 90 ()

This study aimed to investigate the potential molecular mechanism underlying radon-induced lung damage. Our results showed that long-term radon exposu......

JIF:4.623

Dust fall PM2.5-induced lung inflammation in rats is associated with hypermethylation of the IFN-? gene promoter via the PI3K-Akt-DNMT3b pathway

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 95 ()

Inflammation is one of the major adverse effects of fine particulate matter (PM2.5) on the lung system; however, its mechanisms remain unclear. Rats w......

JIF:4.623

DEHP triggers a damage severity grade increase in the jejunum in quail (Coturnix japonica) by disturbing nuclear xenobiotic receptors and the Nrf2-mediated defense response

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 96 ()

As a plasticizer, di-2-ethylhexyl phthalate (DEHP) has been listed as a potential endocrine disruptor by The World Health Organization. The toxicity o......

JIF:4.623

Cis-bifenthrin inhibits cortisol and aldosterone biosynthesis in human adrenocortical H295R cells via cAMP signaling cascade

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 89 ()

Cis-bifenthrin (cis-BF) is a common-used pyrethroid insecticide frequently detected in environmental and biological matrices. Mounting evidence highli......

JIF:4.623

Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 92 ()

The herbicide glyphosate is being used worldwide. Hematological toxicity caused by glyphosate exposure has been reported, but the underlying mechanism......

JIF:4.623

Transgenerational reproductive toxicity of 2,4,6-trinitrotoluene (TNT) and its metabolite 4-ADNT in Caenorhabditis elegans

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 92 ()

2,4,6-trinitrotoluene (TNT) as an energetic compound widely used in military applications has aroused great concerns in recent years due to its large-......

JIF:4.623

Di(2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 95 ()

Di(2-ethylhexyl) phthalate (DEHP) is widely used and has been implicated in hepatotoxicity, although the mechanism is unclear. Here, we investigated t......

JIF:4.623

Relationship between miRNAs polymorphisms and peripheral blood leukocyte DNA telomere length in coke oven workers: A cross-sectional study

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 95 ()

Objective: The purpose of this study was to investigate the factors affecting telomere length (TL) in coke oven workers by analyzing the interaction b......

JIF:4.623

Annexin A1 inhibition facilitates NLRP3 inflammasome activation in arsenic-induced insulin resistance in rat liver

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 96 ()

Hepatic insulin resistance (IR) is the primary pathology of type 2 diabetes (T2D). The role of the NOD-like receptor protein 3 (NLRP3) inflammasome in......

JIF:4.623

Distribution and risk assessment of heavy metals in the economic fish of the Southern Fujian Province

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 92 ()

The distribution and risk assessment of heavy metals (Pb, Cu, Cr, Zn, Cd, As and Hg) in the economic fish of the Southern Fujian Province was acquired......

JIF:4.623

Joint action of binary mixtures based on parameter k-ECx from concentration-response curves in long-term toxicity assay

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 94 ()

A previous acute toxicity study of binary mixtures showed that the combined toxicity can be predicted with the parameter k.ECx. To systematically inve......

JIF:4.623

KIF11, a plus end-directed kinesin, as a key gene in benzo(a) pyrene-induced non-small cell lung cancer

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 89 ()

Evidence indicates that Benzo(a)pyrenediol-epoxide (BPDE) can damage lung cells, resulting in carcinogenesis with complex mechanisms. We aimed to expl......

JIF:4.623

Potentilla anserine L.polysaccharide protects against cadmium-induced neurotoxicity

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 90 ()

Cadmium is a toxic metal that can damage the brain and other organs. This study aimed to explore the protective effects of Potentilla anserine L. poly......

JIF:4.623

Sulfur dioxide-enhanced asthma susceptibility is involved with inhibition of bitter taste transduction in mouse lung

期刊: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022; 95 ()

Sulfur dioxide (SO2) may induce asthma-like symptoms or worsen existing asthma, but the underlying mechanism is still unclear. In this study, the rela......

JIF:4.623

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