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Loss of KMT2D induces prostate cancer ROS-mediated DNA damage by suppressing the enhancer activity and DNA binding of antioxidant transcription factor FOXO3

Lv, SD; Wen, HR; Shan, XW; Li, JH; Wu, YB; Yu, XP; Huang, WH; Wei, Q

Huang, WH (reprint author), Southern Med Univ, Sch Basic Med Sci, Natl Key Discipline Human Anat, Guangzhou 510515, Guangdong, Peoples R China.; Wei, Q (reprint author), Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou 510515, Guangdong, Peoples R Ch

EPIGENETICS, 0; ():

Abstract

Histone methyltransferase KMT2D has diverse functions and distinct mechanisms in different cancers. Although we have previously found KMT2D serves as ......

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