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#脑水肿#

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href='/topic/show?id=6d7610510234' target=_blank style='color:#2F92EE;'>#仑卡奈单抗#</a>（<a href='/topic/show?id=977a1048622c' target=_blank style='color:#2F92EE;'>#Lecanemab#</a>）并用 <a href='/topic/show?id=5f951e023f3' target=_blank style='color:#2F92EE;'>#t-PA#</a> 治疗<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>的患者发生多发性<a href='/topic/show?id=d90484e1883' target=_blank style='color:#2F92EE;'>#脑出血#</a>。主要原因可能与仑卡奈单抗在清除<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>时，导致脑内结构发生改变，虽然淀粉样蛋白对认知有损害，但是它也是脑内细胞结构的重要支撑源，如果它被清除过度或过快，会导致脑水肿，同样<a href='/topic/show?id=1d2f8490308' target=_blank style='color:#2F92EE;'>#脑水肿#</a>又会继发血管的损伤，更容易出现。若与tPA这类溶栓药物合用的话，出血的风险就会大增，甚至与卒中一二级预防药物，如<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>，<a href='/topic/show?id=43666034930' target=_blank style='color:#2F92EE;'>#替格瑞洛#</a>，<a href='/topic/show?id=5a626408e66' target=_blank 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脑水肿

2020-05-29

梅斯管理员 (审核中...)

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#脑水肿# #TRPM4#

南方医科大学AFM：脑靶向脂质纳米颗粒通过抑制TRPM4通道防止脑水肿

2024-05-12发表于上海

循证小兵 (审核中...)

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全文收起 #仑卡奈单抗#（#Lecanemab#）并用 #t-PA# 治疗#缺血性卒中#的患者发生多发性#脑出血#。主要原因可能与仑卡奈单抗在清除#淀粉样蛋白#时，导致脑内结构发生改变，虽然淀粉样蛋白对认知有损害，但是它也是脑内细胞结构的重要支撑源，如果它被清除过度或过快，会导致脑水肿，同样#脑水肿#又会继发血管的损伤，更容易出现。若与tPA这类溶栓药物合用的话，出血的风险就会大增，甚至与卒中一二级预防药物，如#阿司匹林#，#替格瑞洛#，#氯吡格雷#，或#利伐沙班#类联合应用，同样也可能会增加出血风险。因此，对于高卒中风险的#老年性痴呆#人群的用药，还需要进一步开展临床试验，才能保障患者的安全。相信#FDA#可能也会提出同样的要求。

NEJM：1例接受仑卡奈单抗（Lecanemab）并用 t-PA 治疗卒中的患者发生多发性脑出血

2023-01-05发表于上海

gaoxiaoe (审核中...)

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#脑水肿#

血管源性、细胞毒性和间质性脑水肿的鉴别

2022-07-22

docwu2019 (审核中...)

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#脑水肿#

MR入门 | 自由水、结合水、脑水肿的区别？

2022-04-30

gaoxiaoe (审核中...)

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#脑水肿#

European Radiology：这一影像学指标，成为了急性卒中出现恶性脑水肿的新兴预测手段！

2022-04-08

gaoxiaoe (审核中...)

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#脑水肿#

中国「脑出血后脑水肿管理专家共识」

2022-02-18

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：缺血性卒中后，血脑屏障破坏和低灌注，和脑水肿相关

2022-01-11

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：基线梗死体积超过130ml时，血管内治疗加重脑水肿的发生

2021-12-22

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：基线梗死体积超过130ml时，血管内治疗加重脑水肿的发生

2021-12-18

gaoxiaoe (审核中...)

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#脑水肿#

JAMA Neurology：争议中上市的阿尔茨海默病新药，超1/3患者治疗后出现脑水肿

2021-11-26

gaoxiaoe (审核中...)

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#脑水肿#

放疗联合贝伐珠单抗治疗肺腺癌脑转移瘤伴脑水肿的临床效果

2021-11-23

gaoxiaoe (审核中...)

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#脑水肿#

贝伐珠单抗对肺腺癌脑转移伴难治性脑水肿患者生活质量及血清 VEGF水平的影响

2021-11-23

gaoxiaoe (审核中...)

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#脑水肿#

如何鉴别血管源性、细胞毒性、间质性脑水肿？

2021-11-06

gaoxiaoe (审核中...)

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#脑水肿#

临床笔记 | 如何鉴别脑水肿（血管源性、细胞毒性、间质性）？

2021-10-27

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：中性粒细胞与淋巴细胞比值可预测脑卒中患者再灌注治疗后早期脑水肿和临床恶化

2021-02-23

gaoxiaoe (审核中...)

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#脑水肿#

低钠血症合并脑水肿，竟和这种“聪明药”有关

2020-07-22

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：如何快速识别急性缺血性脑卒中后脑水肿？

2020-07-12

gaoxiaoe (审核中...)

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#脑水肿#

Stroke：血管再通降低脑水肿的风险，增加脑实质出血的风险

2020-02-27

gaoxiaoe (审核中...)

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#脑水肿#

Stroke:缺血性卒中后脑脊液减少提示脑水肿风险

2020-02-26

gaoxiaoe (审核中...)

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#脑水肿#

Neurocrit Care:渗透性药物纠正高颅压和脑水肿1例

2019-08-10

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