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[GetTopicListResponse(id=2138151, encodeId=b81e213815104, content=伟大！<a href='/topic/show?id=f336e29134' target=_blank style='color:#2F92EE;'>#FDA#</a>批准了 Krystal Biotech 公司开发的基于<a href='/topic/show?id=ce8b1062e1de' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒1型#</a>（<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>）的<a href='/topic/show?id=ea691062e22c' target=_blank style='color:#2F92EE;'>#局部基因疗法#</a><a href='/topic/show?id=70311062e308' target=_blank style='color:#2F92EE;'>#Beremagene Geperpavec#</a>（B-VEC），商品名<a href='/topic/show?id=6f691062e495' target=_blank style='color:#2F92EE;'>#Vyjuvke#</a>。用于治疗6月龄及以上的伴有<a href='/topic/show?id=06414988ab' target=_blank style='color:#2F92EE;'>#Col7a1#</a>基因突变的<a href='/topic/show?id=0ac21062e5e4' target=_blank style='color:#2F92EE;'>#营养不良大疱性表皮松解症#</a>（DEB）患者的伤口。 <a href='/topic/show?id=2be61e0740' target=_blank style='color:#2F92EE;'>#AAV载体#</a>无法重复给药，而<a href='/topic/show?id=567041e8055' target=_blank 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Biol：HSV-1感染期间广泛激活宿主基因组的反义转录, objectType=article, longId=118743, objectId=bd11118e435e, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=bd11118e435e, replyNumber=0, likeNumber=82, createdTime=2018-02-19, rootId=0, userName=xiaoyeshuang, userId=6eba113, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=bd11118e435e, moduleTitle=Genome Biol：HSV-1感染期间广泛激活宿主基因组的反义转录, moduleType=article, hrefUrl=//www.sandwebs.com/article/show_article.do?id=bd11118e435e)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 风湿免疫小助手

HSV-1

2020-05-29

侠胆医心 (审核中...)

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全文收起伟大！#FDA#批准了 Krystal Biotech 公司开发的基于#单纯疱疹病毒1型#（#HSV-1#）的#局部基因疗法##Beremagene Geperpavec#（B-VEC），商品名#Vyjuvke#。用于治疗6月龄及以上的伴有#Col7a1#基因突变的#营养不良大疱性表皮松解症#（DEB）患者的伤口。 #AAV载体#无法重复给药，而#基因治疗#会随时间推移，疗效逐步降低，看来还需要找到新的载体！HSV-1是其中之一，#慢病毒载体#有天然的缺陷，未来还需要发现更多的载体，或开发新型的#纳米载体#。

FDA批准首个可重复给药基因疗法，每年63万美元，治疗“最痛苦疾病”

2023-05-21发表于上海

xiaoyeshuang (审核中...)

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#HSV-1#

HSV-1G207溶瘤病毒疗法治疗儿童高级别胶质瘤

2022-08-24

xiaoyeshuang (审核中...)

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#HSV-1#

J Periodontal Res：单纯疱疹病毒1型（HSV-1）的存在与牙龈炎和牙周炎的发生有关吗？

2022-10-10

xiaoyeshuang (审核中...)

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#HSV-1#

一文打尽单纯疱疹病毒(HSV-1/HSV-2)的诊疗

2022-03-06

xiaoyeshuang (审核中...)

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#HSV-1#

NEJM：HSV-1G207溶瘤病毒疗法治疗儿童高级别胶质瘤

2021-06-25

xiaoyeshuang (审核中...)

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#HSV-1#

ACS Med Chem Lett:非糖类糖胺聚糖类似物（NSGMs）抑制单纯疱疹病毒1型（HSV-1）进入人体细胞

2018-10-17

xiaoyeshuang (审核中...)

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#HSV-1#

Curr Eye Res：HSV-1感染原代人角膜上皮细胞的长非编码RNA转录特征及整合分析

2018-08-28

xiaoyeshuang (审核中...)

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#HSV-1#

Genome Biol：HSV-1感染期间广泛激活宿主基因组的反义转录

2018-02-19

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