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moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2164835, encodeId=12222164835d7, content=信使RNA（<a href='/topic/show?id=35c21222496' target=_blank style='color:#2F92EE;'>#mRNA#</a>）由于能够产生<a href='/topic/show?id=aa3110e223b6' target=_blank style='color:#2F92EE;'>#功能性蛋白#</a>，被认为是一种潜力巨大的治疗工具，在疫苗，基因编辑和蛋白替代疗法等多个领域具有广泛应用。不同于DNA，mRNA只需要进入细胞质就能产生目标蛋白，降低了基因插入的突变风险。然而，单独的mRNA很容易被血液中的核酸酶所降解而无法进入细胞，因此开发安全高效的<a href='/topic/show?id=9c0b10e2241d' target=_blank style='color:#2F92EE;'>#核酸载体#</a>具有十分重要的意义。<a href='/topic/show?id=f0f910e2255b' target=_blank style='color:#2F92EE;'>#脂质纳米颗粒#</a>（LNP）是目前临床上最具潜力的非病毒核酸载体，但其有限的内涵体逃逸能力，极大地限制了LNP平台发挥全部潜力。, objectTitle=南开大学熊虎研究员JACS：基于模块化策略合成的生物可降解可电离脂质用于提高mRNA体内递送效率与癌症转移精准成像, objectType=article, longId=797654, objectId=bcbfe9765460, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/hospital-staff-doctor-review-PTX6YZP.jpg, objectUrl=/article/show_article.do?id=bcbfe9765460, 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objectUrl=/article/show_article.do?id=aee9203e8243, replyNumber=0, likeNumber=176, createdTime=2020-11-26, rootId=0, userName=BJying, userId=fb825296401, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=aee9203e8243, moduleTitle=Moderna宣布欧盟委员会批准COVID-19疫苗（mRNA-1273）的首批8000万剂的预购协议, moduleType=article, hrefUrl=//www.sandwebs.com/article/show_article.do?id=aee9203e8243)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 风湿免疫小助手

mRNA

2020-05-29

梅斯管理员 (审核中...)

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#mRNA#

2024-09-10发表于上海

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#mRNA# #癌症疫苗#

Nat Med：mRNA技术推动个性化癌症疫苗革命

2024-09-03发表于上海

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#mRNA# #特发性肺纤维化# #脂质纳米粒#

上海交大《自然·通讯》：优化吸入LNP配方，强化mRNA介导的特发性肺纤维化抗体治疗特发性肺纤维化

2024-08-13发表于上海

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#mRNA# #肿瘤疫苗#

大咖谈 | mRNA肿瘤疫苗

2024-07-15发表于上海

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#mRNA# #ZAK# #紫外线辐射#

2024-07-14发表于上海

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#mRNA# #细胞衰老# #RNA 聚合酶 II#

2024-02-28发表于上海

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#mRNA# #circRNA# #环状 RNA#

2024-02-27发表于上海

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#mRNA# #髓母细胞瘤# #胶质母细胞瘤#

基因组医学| 脑肿瘤mRNA新产品和相关疫苗的开发和应用

2024-02-18发表于陕西省

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#mRNA# #tRNA# #密码子# #肌苷#

2024-01-28发表于上海

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#mRNA# #肿瘤疫苗# #HPV感染#

远大医药创新mRNA治疗性肿瘤疫苗ARC01国内IND获批，或填补HPV阳性肿瘤治疗市场空白

2024-01-24发表于上海

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#mRNA# #核糖体# #N1-甲基假尿苷#

2023-12-31发表于上海

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#mRNA# #等位基因# #单倍剂量不足基因# #MSL2#

2023-12-28发表于上海

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#白血病# #mRNA# #NSUN2低表达# #SRSF2P95H#

Mol Cell | 北京基因组所杨运桂团队及合作者揭示表观转录组学与癌症的“意外”关联

2023-12-26发表于上海

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#mRNA# #剪接体# #内含子#

2023-12-25发表于上海

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#胰腺癌# #mRNA# #胰腺导管癌#

攻克“癌王”的潜在利器有哪些？Cancer重磅：盘点胰腺癌“最关键”治疗进展

2023-12-06发表于上海

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#mRNA# #斑马鱼# #sci-Plex# #脊索#

2023-11-24发表于上海

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全文收起信使RNA（#mRNA#）由于能够产生#功能性蛋白#，被认为是一种潜力巨大的治疗工具，在疫苗，基因编辑和蛋白替代疗法等多个领域具有广泛应用。不同于DNA，mRNA只需要进入细胞质就能产生目标蛋白，降低了基因插入的突变风险。然而，单独的mRNA很容易被血液中的核酸酶所降解而无法进入细胞，因此开发安全高效的#核酸载体#具有十分重要的意义。#脂质纳米颗粒#（LNP）是目前临床上最具潜力的非病毒核酸载体，但其有限的内涵体逃逸能力，极大地限制了LNP平台发挥全部潜力。

南开大学熊虎研究员JACS：基于模块化策略合成的生物可降解可电离脂质用于提高mRNA体内递送效率与癌症转移精准成像

2023-10-25发表于上海

BJying (审核中...)

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#新冠肺炎# #mRNA# mRNA·疫苗势头大好，走了新冠肺炎疫苗头阵。也为后续其他新冠肺炎疫苗的研发与生产做了一个表率。

Moderna宣布欧盟委员会批准COVID-19疫苗（mRNA-1273）的首批8000万剂的预购协议

2020-11-26

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