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#细胞衰老#

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encodeId=65882131384eb, content=<a href='/topic/show?id=715ae8023ea' target=_blank style='color:#2F92EE;'>#细胞衰老#</a>细胞衰老是衰老的主要标志，与许多年龄相关疾病的发病机制相关，包括神经退行性变、动脉粥样硬化和代谢性疾病等。因此减少或延缓衰老过程中衰老细胞的积累可改善与年龄相关疾病的发生和进展。 microRNA-449a-5p (miR-449a) 是一种小非编码 RNA，在正常小鼠中随年龄增长而下调，但在生长激素 (GH) 缺陷型 Ames Dwarf (df/df) 小鼠中保持不变，且其寿命比正常同窝小鼠长 40% 至 60%。在df/df小鼠中，GH治疗与衰老负担增加之间存在直接相关性，这表明GH与诱导前脂肪细胞加速衰老有关，包括脂肪来源的干细胞。, objectTitle=细胞衰老, objectType=topic, longId=78023, objectId=null, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=null, replyNumber=0, likeNumber=83, createdTime=2023-05-10, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2115013, encodeId=bbcd211501369, content=<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>还是许多常见疾病（如癌症、<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>、心脏病、神经退化等）的根源。幸运的是，科学家们在衰老领域取得了令人惊叹的进展，特别是发现了一些可以用来判断和评估衰老程度的特征和标志物。<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a><a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a><a href='/topic/show?id=3afd2430241' target=_blank style='color:#2F92EE;'>#亚精胺#</a><a href='/topic/show?id=c65410445387' target=_blank style='color:#2F92EE;'>#尿苷#</a><a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a><a href='/topic/show?id=0714105280c4' target=_blank style='color:#2F92EE;'>#基因组稳定性#</a><a href='/topic/show?id=5b109025320' target=_blank style='color:#2F92EE;'>#表观遗传学#</a><a href='/topic/show?id=715ae8023ea' target=_blank style='color:#2F92EE;'>#细胞衰老#</a><a href='/topic/show?id=9a961052819f' target=_blank style='color:#2F92EE;'>#humanin#</a><a href='/topic/show?id=dfc32242d1' target=_blank style='color:#2F92EE;'>#AKK菌#</a><a href='/topic/show?id=a88e104838d5' target=_blank style='color:#2F92EE;'>#Senolytics#</a><a href='/topic/show?id=a727696058f' target=_blank style='color:#2F92EE;'>#生酮饮食#</a><a href='/topic/show?id=732f9e270a7' target=_blank style='color:#2F92EE;'>#间歇性断食#</a>，太多的关键词了，这些都与衰老有关，不过，从整体而言，心理平和（不<a href='/topic/show?id=87206e28215' target=_blank style='color:#2F92EE;'>#焦虑#</a>），适度<a href='/topic/show?id=babc9413eb6' target=_blank style='color:#2F92EE;'>#运动#</a>，合理膳食，再加上适当的<a href='/topic/show?id=8c222e15402' target=_blank style='color:#2F92EE;'>#保健品#</a>，及时进行疾病筛查和治疗，这可能是<a href='/topic/show?id=d06e55e807f' target=_blank style='color:#2F92EE;'>#抗衰老#</a>的关键因素。, objectTitle=Cell重磅综述：衰老的十二大特征, objectType=article, longId=759765, objectId=124de59765f8, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20230111/dfcb06f8b64d4056b6bb51656017bda1.jpg, 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细胞衰老

2020-05-29

梅斯管理员 (审核中...)

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#细胞衰老# #抗肿瘤治疗# #衰老细胞治疗# #衰老逃逸#

衰老细胞治疗：协同抗肿瘤治疗的新策略

昨天发表于上海

梅斯管理员 (审核中...)

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#衰老# #细胞衰老# #IL-11#

Nature重磅：抗衰老新靶点，可延长寿命25%！抗衰的“终极奥义”是抗炎？

2024-09-12发表于上海

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#骨关节炎# #细胞衰老# #天冬酰胺β-羟化酶#

重庆医科大郭风劲教授团队《自然·通讯》：揭示天然小分子药物10-HDA在骨关节炎进展中的保护作用和机制

2024-09-06发表于上海

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#细胞衰老# #治疗靶点# #诊断标志物# #肾小球相关性糖尿病肾病#

Front Immunol：南方医科大学基于细胞衰老的肾小球相关性糖尿病肾病潜在诊断标志物和治疗靶点的综合分析

2024-07-24发表于上海

梅斯管理员 (审核中...)

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#细胞衰老# #SenCID#

Cell Metab：北京大学韩敬东团队揭示了衰老异质性、轨迹和调节剂

2024-04-14发表于陕西省

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#衰老# #细胞衰老# #牛磺酸#

Science：血液牛磺酸缺乏驱动衰老

2024-04-05发表于威斯康星

梅斯管理员 (审核中...)

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#mRNA# #细胞衰老# #RNA 聚合酶 II#

2024-02-28发表于上海

ms1000000687639315 (审核中...)

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#细胞衰老# #插入话题#

2023-12-22发表于江苏省

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#心血管# #心血管事件# #衰老# #细胞衰老# #抗衰老#

Nature Rev Cardio：心血管衰老的八大标志

2023-12-11发表于威斯康星

yangchou (审核中...)

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全文收起 #细胞衰老#细胞衰老是衰老的主要标志，与许多年龄相关疾病的发病机制相关，包括神经退行性变、动脉粥样硬化和代谢性疾病等。因此减少或延缓衰老过程中衰老细胞的积累可改善与年龄相关疾病的发生和进展。 microRNA-449a-5p (miR-449a) 是一种小非编码 RNA，在正常小鼠中随年龄增长而下调，但在生长激素 (GH) 缺陷型 Ames Dwarf (df/df) 小鼠中保持不变，且其寿命比正常同窝小鼠长 40% 至 60%。在df/df小鼠中，GH治疗与衰老负担增加之间存在直接相关性，这表明GH与诱导前脂肪细胞加速衰老有关，包括脂肪来源的干细胞。

2023-05-10

showtest (审核中...)

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全文收起 #衰老#还是许多常见疾病（如癌症、#糖尿病#、心脏病、神经退化等）的根源。幸运的是，科学家们在衰老领域取得了令人惊叹的进展，特别是发现了一些可以用来判断和评估衰老程度的特征和标志物。#二甲双胍##雷帕霉素##亚精胺##尿苷##自噬##基因组稳定性##表观遗传学##细胞衰老##humanin##AKK菌##Senolytics##生酮饮食##间歇性断食#，太多的关键词了，这些都与衰老有关，不过，从整体而言，心理平和（不#焦虑#），适度#运动#，合理膳食，再加上适当的#保健品#，及时进行疾病筛查和治疗，这可能是#抗衰老#的关键因素。

Cell重磅综述：衰老的十二大特征

2023-02-17发表于上海

ms8543593053280928 (审核中...)

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#细胞衰老#

Nature Cell Biology：刘苹羽/张如刚等揭示RNA编辑酶ADAR1调控细胞衰老的新功能和机制

2022-07-21

ms8543593053280928 (审核中...)

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#细胞衰老#

Nature子刊：端粒氧化损伤可以触发细胞衰老

2022-07-12

ms8543593053280928 (审核中...)

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#细胞衰老#

A&R：白细胞介素4诱导的上皮细胞衰老对IgG4相关性唾液腺炎的新治疗靶点

2022-06-23

ms8543593053280928 (审核中...)

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#细胞衰老#

ARD：机械超载通过下调FBXW7促进软骨细胞衰老和骨关节炎发展

2022-05-06

ms8543593053280928 (审核中...)

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#细胞衰老#

Nature Aging：刘光慧/曲静等揭示载脂蛋白E在细胞衰老中的作用

2022-03-31

ms8543593053280928 (审核中...)

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#细胞衰老#

Thorax：吸入糖皮质激素延缓COPD患者内皮祖细胞衰老

2022-03-16

ms8543593053280928 (审核中...)

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#细胞衰老#

ARD：METTL3介导的ATG7的m6A修饰调节自噬-GATA4轴以促进细胞衰老和骨关节炎进展

2021-11-06

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#细胞衰老#

JCI: 肺动脉高压与内皮细胞衰老，Frataxin新发现

2021-09-30

ms8543593053280928 (审核中...)

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#细胞衰老#

新冠病毒会导致细胞衰老，钟南山院士团队首次描绘德尔塔变异株完整传播链 | 新冠研究一周进展

2021-09-24

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