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capivasertib

2020-05-29

梅斯管理员 (审核中...)

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#三阴性乳腺癌# #capivasertib#

首创AKT抑制剂capivasertib治疗三阴性乳腺癌III期临床失败！

2024-06-28发表于加利福尼亚

梅斯管理员 (审核中...)

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#乳腺癌# #capivasertib#

【专家访谈】Capivasertib获批HR+/HER2-乳腺癌，临床使用时应关注哪些问题？

2024-01-07发表于陕西省

侠胆医心 (审核中...)

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全文收起 #capivasertib#是一种口服可利用的小分子抑制剂，可以抑制所有三种AKT亚型。因此毒性还是相当大的！AKT的信号太上游了，安全性恐怕难以过关。与单独使用富马酸#fulvestrant#相比，添加#卡匹曲塞替#治疗显著改善了#激素受体阳性晚期乳腺癌#患者的无进展生存期，这些患者在之前的内分泌治疗期间或之后出现疾病进展，可能合并#CDK4/6抑制剂#使用或未使用。腹泻和皮疹是接受卡匹曲塞替治疗的患者主要的不良事件。样本量大了以后，可能还会有更多的副作用出现#乳腺癌##氟维司群#

NEJM：Capivasertib对HR阳性乳腺癌的治疗效果（CAPItello-291研究）

2023-06-02发表于上海

智智灵药 (审核中...)

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#capivasertib#

Lancet Oncol：氟维司群联合Capivasertib治疗芳香化酶抑制剂耐药性晚期/复发性ER+HER2-乳腺癌

2022-06-14

智智灵药 (审核中...)

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#capivasertib#

ASCO 2022 | FAKTION临床：capivasertib+氟维司群，改善芳香化酶抑制剂耐药MBC患者生存！

2022-06-12

智智灵药 (审核中...)

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#capivasertib#

J Clin Oncol：Capivasertib联合多西他赛和泼尼松龙治疗转移性去势抵抗性前列腺癌

2020-12-30

智智灵药 (审核中...)

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#capivasertib#

Lancet Oncol：Capivasertib联合氟维司群可显著延长晚期乳腺癌患者的无进展存活期

2020-02-14

智智灵药 (审核中...)

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#capivasertib#

AKT抑制剂capivasertib联合氟维司群显著改善HR+晚期乳腺癌无进展生存

2019-06-11

智智灵药 (审核中...)

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#capivasertib#

ASCO 2019：AKT抑制剂capivasertib联合氟维司群显著改善HR+HER2-晚期乳腺癌结局

2019-06-10

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